Breast cancer report + child's examination issues?
Hello, about a month ago I was diagnosed with breast cancer.
Two weeks ago, I underwent a left modified radical mastectomy at Chang Gung Memorial Hospital.
I have now received a pathology report, and when I asked my doctor, he didn't say much, only mentioning that it is stage III breast cancer and that I will need chemotherapy.
Below is the report; I would appreciate it if you could take the time to help me translate it.
DX: Breast, left, modified radical mastectomy - invasive lobular carcinoma, pT2N3a, margin negative - lobular carcinoma in situ, margin negative - ductal carcinoma in situ, high grade, margin negative
Lymph nodes, left axillary (level 1), excision - metastatic lobular carcinoma (2/2)
Lymph nodes, left axillary (level 1 and II), excision - metastatic lobular carcinoma (16/18)
Lymph nodes, left Rotter's, excision - metastatic lobular carcinoma (1/2)
GROSS DESCRIPTION:
1.
Breast: (2) left
2.
Tumor location: (1) central
3.
Type of mastectomy: (1) modified radical
4.
Size of breast tissue removed: 16.3 x 15.4 x 3.5 cm
5.
Size of skin attached: 11.0 x 5.8 x 0.1 cm
6.
Size of axillary fat pad: 3.2 x 2.2 x 1.0 cm
7.
Gross residual tumor: (1) yes
8.
Tumor involvement: (1) one area
9.
Size of tumor: 3.8 x 3.5 x 1.7 cm
10.
Tumor description: firm, gray-white, infiltrative border
11.
Nearest resection margin: (1) free (0.4 cm to deep margin)
12.
Specimen fixed in 10% neutral buffered formalin for: (1) 6-48 hours
Sections taken are labeled as:
T1-4: 2 slices of tumor with greatest tumor dimension (T1-2, T3-4: conjoined)
E: Breast, non-tumor
S: Skin
N: Nipple
L1: Level 1 lymph nodes in axillary fat pad
L2-5: lymph nodes labeled "level 1 & II"
L6: Rotter's nodes
Gross Description (Cont):
Specimen retrieval time: 2016/2/2 10:15
Fixation time: 2016/2/2 11:19
MICRO DESCRIPTION:
1.
Ductal carcinoma in situ
I.
Tumor size: 1.5 cm
II.
Tumor grade: (3) high grade
III.
Nuclear grade: (3) high grade
IV.
Necrosis: (1) large area
This is the general content of the report.
I had a hysterectomy around 2008/2009, so I have been menopausal since then.
I am wondering if this might have contributed to my breast cancer.
I am concerned about my older son (now 26 years old), younger son (now 20 years old), and daughter (now 15 years old) and whether they will have a higher risk of developing breast cancer in the future.
How often should they get screened for safety? If I have any other questions, I will consult you and your team again.
Thank you.
Miss Jian, 50~59 year old female. Ask Date: 2016/02/23
Dr. Zhou Jiazhen reply Breast and Thyroid
Dear Ms.
Chien:
1.
For Stage III C, which is classified as locally advanced breast cancer, there is a high likelihood of metastasis.
Chemotherapy is necessary, and the tumor size ranges from 2 to 5 cm, with lymph node involvement exceeding 10 nodes.
However, I have not seen any reports regarding the specific histological type of this breast cancer.
Is it classified as Luminal A or B, targeted therapy breast cancer, or triple-negative breast cancer? What are the ER, PR, HER2, and Ki-67 status? These factors are relevant to subsequent treatment.
2.
In the case of a hysterectomy, if the ovaries are still present, there will still be hormonal stimulation, which may suggest a stronger correlation between breast cancer and hormones, rather than the hysterectomy itself.
3.
Your daughter should begin self-examinations after her menstrual cycle.
If there are no abnormalities, she should start seeing a healthcare provider for examinations around the age of 30.
Reply Date: 2016/02/23
More Info
I'm sorry to hear about your recent diagnosis and the challenges you and your family are facing. Understanding breast cancer, especially in the context of family history and genetic risk factors, is crucial for both treatment and prevention strategies.
Breast cancer can indeed have a hereditary component, particularly in families with a history of breast and ovarian cancers. The BRCA1 and BRCA2 genes are well-known for their association with increased breast cancer risk. However, having normal BRCA genes does not eliminate the risk of developing breast cancer; it merely reduces the likelihood compared to those with mutations in these genes.
Given your family history and your recent diagnosis of stage III invasive lobular carcinoma, it is understandable to be concerned about the potential risks for your children. While breast cancer can be influenced by genetic factors, it is also significantly affected by environmental factors and lifestyle choices. The risk of breast cancer in your children may be higher than the general population, especially if there are multiple family members with breast or related cancers. However, the exact risk can vary widely and is influenced by many factors, including age, lifestyle, and overall health.
For your children, regular screenings can be an important preventive measure. The American Cancer Society recommends that women at average risk begin annual mammograms at age 45, with the option to start at age 40. However, for those with a family history of breast cancer, especially first-degree relatives (like a mother or sister), it may be advisable to start screening earlier. In your case, considering your diagnosis and family history, your children might benefit from starting screenings in their late teens or early twenties, depending on their individual risk factors and discussions with their healthcare providers.
In terms of your own health, after a diagnosis of breast cancer, it is essential to follow your oncologist's recommendations regarding treatment and follow-up care. Chemotherapy is often recommended for stage III breast cancer to reduce the risk of recurrence and manage any remaining cancer cells. Your oncologist will also monitor your response to treatment through regular check-ups and possibly imaging studies.
Regarding your concerns about menopause and its relation to breast cancer, while some studies suggest that early menopause can influence breast cancer risk, the relationship is complex. Factors such as hormone replacement therapy, lifestyle, and genetic predisposition play significant roles in breast cancer development.
It's also important to maintain a healthy lifestyle during and after treatment. This includes a balanced diet rich in fruits, vegetables, whole grains, and lean proteins, regular physical activity, and avoiding tobacco and excessive alcohol consumption. These lifestyle factors can help improve overall health and may reduce the risk of cancer recurrence.
Lastly, if you have further questions or concerns, don't hesitate to reach out to your healthcare team. They can provide personalized advice based on your medical history and current health status. Support groups and counseling can also be beneficial for both you and your family as you navigate this journey. Remember, you are not alone, and there are resources available to help you through this challenging time.
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