Fever After Vaccination: What Parents Should Know About Infant Reactions - Pediatrics

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Fever reaching 39 degrees Celsius after vaccination?


Hello, doctor! My baby is two months old.
He received the 13-valent pneumococcal vaccine and the pentavalent vaccine the morning before yesterday, and he started having a fever last night, with a maximum temperature of 39 degrees Celsius.
Could this be related to the vaccines, or could there be another issue? Should I take him to see a doctor?

Qun, 40~49 year old female. Ask Date: 2016/02/28

Dr. Xiao Kaiwen reply Pediatrics


If fever occurs after administering the pentavalent vaccine and the 13-valent pneumococcal vaccine, it typically happens within 24 hours of vaccination and usually does not last more than 24 hours.
Therefore, your child may have another illness causing the fever, and it is recommended to visit a pediatric department at a major hospital for evaluation.

Reply Date: 2016/02/28

More Info


When it comes to infants receiving vaccinations, it's not uncommon for parents to be concerned about potential side effects, including fever. In your case, your two-month-old baby received the 13-valent pneumococcal vaccine and a combination vaccine (often referred to as the "five-in-one" vaccine), and subsequently developed a fever reaching up to 39 degrees Celsius (102.2 degrees Fahrenheit).
First and foremost, it is important to understand that mild fever is a common and expected reaction following vaccinations. Vaccines work by stimulating the immune system to recognize and fight off pathogens, and this immune response can sometimes manifest as fever. According to the Centers for Disease Control and Prevention (CDC), common side effects of vaccines can include fever, irritability, and localized redness or swelling at the injection site.
In the case of the pneumococcal vaccine and the five-in-one vaccine, both are known to potentially cause mild fever. The fever typically occurs within 24 to 48 hours after vaccination and usually resolves on its own within a couple of days. The fever is generally not a cause for alarm unless it is particularly high or persistent, or if the child exhibits other concerning symptoms.

Here are some guidelines for parents to consider when their infant develops a fever after vaccination:
1. Monitor the Fever: Keep track of your baby's temperature. A fever of 39 degrees Celsius is considered moderate. If the fever persists for more than 48 hours or if it rises above 40 degrees Celsius (104 degrees Fahrenheit), it is advisable to consult a healthcare professional.

2. Comfort Measures: Ensure your baby is comfortable. You can dress them in light clothing and keep the room at a comfortable temperature. Offering fluids is also important to prevent dehydration.

3. Medication: If your baby seems uncomfortable due to the fever, you may consider administering age-appropriate doses of acetaminophen (Tylenol) or ibuprofen (Advil, Motrin) to help reduce the fever. However, always consult with your pediatrician before giving any medication to ensure it is appropriate for your child's age and weight.

4. Watch for Other Symptoms: Be vigilant for any additional symptoms that may indicate a more serious condition, such as persistent crying, difficulty breathing, rash, or lethargy. If any of these symptoms occur, seek medical attention promptly.

5. Consult Your Pediatrician: If you are ever in doubt about your child's health, it is always best to consult your pediatrician. They can provide guidance tailored to your child's specific situation and health history.

In summary, while it is common for infants to develop a mild fever after vaccinations, it is essential to monitor their condition and provide comfort. If the fever is high, persistent, or accompanied by other concerning symptoms, do not hesitate to seek medical advice. Vaccination is a crucial step in protecting your child's health, and understanding the potential reactions can help alleviate parental anxiety.

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