Heart Medication: Addressing Atrial Fibrillation Concerns - Cardiology

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Cardiac medication consultation


Hello Director He, I would like to consult you again regarding a medication issue.
My mother is 65 years old and has a history of atrial fibrillation.
Four months ago, her cardiologist prescribed Digoxin 150 mg to be taken three times a day.
Her atrial fibrillation has been well controlled, but recently, over the past week, she has noticed a sensation of her heart "pausing" for a moment around 2-3 PM (she reports no discomfort during these episodes).
After some time, her heart rhythm returns to normal, and this sensation does not occur at other times of the day.
She takes her first dose of Digoxin at 8 AM, the second at 12 PM, and the third at 6:30 PM.
I am wondering if the timing of her morning and noon doses being too close (about 4 hours apart) could lead to a peak in drug concentration, causing this afternoon "pause" in her heartbeat? Or could there be other possible reasons for this? Is there any significant impact on her health? I appreciate your time in addressing these questions, and thank you sincerely for your help.
*Previously, I consulted her cardiologist about the "pause" in her heartbeat, and the doctor indicated that it does not affect her overall condition.*

JJ, 30~39 year old female. Ask Date: 2016/03/13

Dr. He Dongjin reply Cardiology


Hello, if the medication concentration is too strong, it should not cause a sudden pause; it may still be due to paroxysmal arrhythmia.
For instance, premature ventricular contractions typically do not have significant effects on the body, so there is no need to panic.
Changhua Hospital is concerned about you.

Reply Date: 2016/03/13

More Info


Atrial fibrillation (AF) is a common cardiac arrhythmia that can lead to various complications, including stroke and heart failure. The medication your mother is taking, Digoxin (心利正), is often prescribed to help control heart rate and improve heart function in patients with AF. It is important to monitor the effects of this medication, especially as it can have side effects and interactions that may influence heart rhythm.

The sensation of a "pause" or "skipped beat" in the heart, known as a palpitations, can be concerning for patients and their families. In your mother's case, the fact that she experiences this sensation primarily in the afternoon and not at other times could be related to several factors. One possibility is that it could be a benign phenomenon, particularly if it occurs without any accompanying symptoms such as dizziness, chest pain, or shortness of breath.
Regarding the timing of her medication, it is unlikely that the close dosing schedule of Digoxin (4 hours apart) is the sole cause of the afternoon sensation. Digoxin has a relatively long half-life, and its effects can last beyond the immediate dosing period. However, fluctuations in drug levels can occur, especially if there are changes in kidney function, hydration status, or dietary intake (such as potassium levels), which can affect Digoxin's efficacy and safety.

It's also worth noting that the heart's electrical system can be sensitive to various factors, including stress, caffeine intake, or even changes in body position. If your mother is experiencing this sensation consistently, it would be prudent to keep a diary of when these episodes occur, along with any other activities or dietary changes that might coincide with them. This information can be valuable for her healthcare provider.

In terms of potential impacts on her health, if the episodes are infrequent and not associated with any distressing symptoms, they may not pose a significant risk. However, it is essential to communicate these occurrences to her cardiologist. They may recommend further evaluation, such as an electrocardiogram (ECG) or a Holter monitor, to assess her heart rhythm over a more extended period. This can help determine if there are any underlying issues that need to be addressed.

In summary, while the sensation of a "pause" in heartbeats can be alarming, it may not necessarily indicate a serious problem, especially if it is not accompanied by other symptoms. However, ongoing communication with her healthcare provider is crucial to ensure her treatment plan is effective and safe. Regular follow-ups and monitoring of her heart condition, along with any necessary adjustments to her medication regimen, will help manage her atrial fibrillation effectively.

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