Medication Interactions: Managing Hypertension and Insomnia - Pharmacology

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Medication issues


Hello, Dr.
Hou.
I have been taking medication for high blood pressure for about ten years and have been on insomnia medication for nearly four years.
Recently, I have been experiencing nausea more often when taking my medication.
Can long-term use of Western medicine harm the stomach? Dr.
Hou, could you please tell me what the insomnia medications, Lipeizheng (a tranquilizer) and calcium carbonate 500 mg, are used for? Are they effective in treating insomnia?
Additionally, Dr.
Hou, yesterday after taking a shower, I felt a sharp pain in my heart.
I coughed once and felt better, but I still have chest pain.
Today, I visited my clinic doctor, who prescribed me a new medication called Shiquanli Xiaojing 5 mg, instructing me to take it along with my high blood pressure medication after dinner.
I am concerned about potential side effects of this new medication and whether it might interact negatively with my insomnia medication.

Mr. Tsai, 30~39 year old female. Ask Date: 2016/03/19

Dr. Hou Fangmin reply Pharmacology


Hello Mr.
Tsai: Hypertension is a common condition among the elderly, but it can be managed with attention.
1.
CLONAZEPAM (Klonopin 0.5 mg): This medication has multiple uses, including aiding sleep and alleviating anxiety.
Please avoid alcohol while taking this medication.
Calcium carbonate: This is a calcium supplement that helps improve osteoporosis; some individuals may experience mild bloating as a side effect, which varies from person to person.
2.
NICORANDIL (Sigmart): This medication is used for angina and has a synergistic pharmacological effect: it provides myocardial protection.
It dilates both large and small coronary arteries, increasing blood flow to the heart.
It also dilates veins and arteries, reducing preload and afterload, thereby decreasing the heart's oxygen demand.
Therefore, it is effective for various types of angina.
In individuals with liver dysfunction, its metabolism may be slightly prolonged.
The side effects of Nicorandil include headaches (3.60%), and less commonly, nausea, vomiting (0.44%), dizziness (0.15%), facial flushing (0.14%), and fatigue (0.12%).
A small number of people may experience these side effects, which vary individually.
We just need to be cautious; if you are taking Viagra, do not use it in conjunction with NICORANDIL (Sigmart), as this combination may enhance the hypotensive effect.
3.
Since I am unaware of the specific antihypertensive medications you are taking, the medications you are currently using do not have any known interactions.
The weather has been a bit cool lately, so if you have angina, please dress warmly.
You should regularly monitor your blood pressure and visit your doctor to discuss your symptoms clearly.
When receiving your medications, also pay attention to the warnings on the prescription bag.
Finally, I wish you peace and well-being.

Reply Date: 2016/03/19

More Info


Hello! Thank you for your questions regarding your medication regimen and concerns about hypertension, insomnia, and potential medication interactions. Let's break down your inquiries and provide some clarity.

Firstly, it's important to understand that managing hypertension (high blood pressure) and insomnia often requires a careful selection of medications, as certain drugs can interact with each other and may lead to side effects. You mentioned that you have been on medication for hypertension for about ten years and have been taking insomnia medication for nearly four years. It's not uncommon for patients on long-term medication to experience side effects, including gastrointestinal issues like nausea or reflux, especially if the medications are not taken with food or if they irritate the stomach lining.

Regarding the specific medications you mentioned—利平靜錠 (likely a form of tranquilizer or sedative) and 碳酸鈣錠 (calcium carbonate)—the former is typically used to help with anxiety and insomnia, while the latter is often used as an antacid or calcium supplement. Calcium carbonate can help with stomach upset, but it is not a treatment for insomnia. If you are experiencing nausea or reflux, it may be beneficial to take these medications with food or to discuss with your doctor the possibility of adjusting your regimen.

You also mentioned experiencing chest pain after showering, which improved after coughing. While occasional chest discomfort can be benign, especially if it resolves quickly, it is crucial to take any new or unusual chest pain seriously. The fact that your doctor prescribed 十全力狭錠 (which I assume is a medication for hypertension or heart-related issues) suggests that they are taking your symptoms seriously. This medication may have side effects, including dizziness, fatigue, or gastrointestinal discomfort, which could potentially interact with your insomnia medication.

When combining medications, especially those affecting the central nervous system (like sedatives) and cardiovascular medications, it is essential to monitor for any adverse effects. Some common side effects of sedatives include drowsiness, dizziness, and confusion, which could be exacerbated by blood pressure medications. Therefore, it is advisable to keep your healthcare provider informed about all the medications you are taking, including over-the-counter drugs and supplements.

In terms of managing your hypertension and insomnia, here are a few recommendations:
1. Regular Monitoring: Keep track of your blood pressure and any symptoms you experience. This information is vital for your healthcare provider to make informed decisions about your treatment.

2. Medication Timing: Take your medications as prescribed, and consider the timing of your doses. For example, taking blood pressure medication in the evening may help with nighttime blood pressure control, while sedatives should be taken close to bedtime.

3. Lifestyle Modifications: Incorporate lifestyle changes such as a balanced diet, regular exercise, and stress management techniques, which can significantly impact both hypertension and insomnia.

4. Consult Your Doctor: If you continue to experience side effects or if your symptoms worsen, it is crucial to consult your healthcare provider. They may need to adjust your medications or explore alternative treatments.

5. Avoid Self-Medication: Be cautious with over-the-counter medications or supplements, as they can interact with your prescribed medications.

In conclusion, managing hypertension and insomnia requires a comprehensive approach that includes medication management, lifestyle changes, and regular communication with your healthcare provider. If you have any further questions or concerns, don't hesitate to reach out to your doctor for personalized advice. Your health and well-being are of utmost importance, and your healthcare team is there to support you.

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