Heart Medication: Concerns About Myocardial Ischemia and Side Effects - Pharmacology

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Could you please provide more details about the medication?


Dear pharmacist, I went to Chang Gung Hospital last November for a cardiac ultrasound and a stress electrocardiogram.
The report indicated that the doctor suspected I might have myocardial infarction, but the doctor at Chang Gung was uncertain and did not prescribe any medication.
I took the report to my clinic where I receive treatment for hypertension, and the doctor there, who is also a cardiologist, reviewed the report and said there was no evidence of myocardial infarction.
The clinic doctor prescribed me a medication called Amlodipine 60 mg.
I have been taking it for over seven months, but recently I have been experiencing intermittent chest pain.
Will this medication harm my heart? The clinic doctor mentioned that this medication is for the prevention of myocardial infarction and advised me to take it daily, stating that I should not stop taking it on my own.
If I don’t take it, will the chest pain improve?

Cai Xiansheng, 30~39 year old female. Ask Date: 2016/05/07

Dr. Hou Fangmin reply Pharmacology


Hello Mr.
Tsai:
1.
The primary pharmacological action of Apresoline (Isosorbide dinitrate) is its active metabolite, which relaxes the smooth muscle of blood vessels, resulting in vasodilation of both arteries and veins.
This medication is used to prevent angina attacks.
Regarding drug interactions, when Apresoline is taken concurrently with Viagra (sildenafil), it may significantly enhance the hypotensive effects, potentially leading to severe side effects such as syncope or myocardial infarction.
Therefore, patients being treated with Apresoline should not use Viagra.
These are important considerations regarding this medication.
2.
Does the medication harm the heart? No, it is used to prevent angina attacks.
3.
Since you have been taking it for over seven months, it would be advisable to have your physician conduct blood tests, an electrocardiogram, and a cardiac ultrasound to assess your condition, which may help in adjusting your medication.
Wishing you good health.

Reply Date: 2016/05/07

More Info


When it comes to understanding heart medication, particularly in the context of myocardial ischemia and the associated side effects, it is crucial to have a comprehensive understanding of both the condition and the medications prescribed. Based on your situation, it appears that you have undergone various cardiac evaluations, including echocardiograms and exercise electrocardiograms, which have raised concerns about potential myocardial ischemia. However, the interpretations of these tests have varied among different healthcare providers, leading to some confusion regarding your diagnosis and treatment.

Myocardial ischemia occurs when blood flow to the heart muscle is reduced, preventing it from receiving enough oxygen. This can lead to symptoms such as chest pain, discomfort, or even heart attacks if not addressed. The medication you mentioned, "Amlodipine," is a calcium channel blocker commonly used to treat high blood pressure and angina (chest pain). It works by relaxing the blood vessels, which can help improve blood flow and reduce the heart's workload. While it is generally well-tolerated, like all medications, it can have side effects.

In your case, the fact that you have been experiencing intermittent chest pain after taking Amlodipine for several months raises some important considerations. First, it is essential to differentiate whether the chest pain is related to the medication or if it is a manifestation of underlying cardiac issues. Amlodipine is not typically associated with causing myocardial ischemia; rather, it is intended to prevent it. However, some patients may experience side effects such as swelling, dizziness, or palpitations, which could be mistaken for cardiac symptoms.

Given that your doctor has advised you to continue taking Amlodipine daily, it is crucial to follow their guidance unless you experience severe side effects or have significant concerns. Stopping the medication abruptly without consulting your healthcare provider could lead to a rebound effect, potentially worsening your condition. If you feel that the medication is causing adverse effects or if your symptoms are worsening, it is vital to communicate this with your healthcare provider. They may consider adjusting your dosage or exploring alternative medications that may be better suited for your situation.

Additionally, it is essential to maintain regular follow-ups with your healthcare provider to monitor your heart health. If your symptoms persist or worsen, further diagnostic tests may be warranted to rule out any significant underlying issues. These could include advanced imaging techniques or even a referral to a cardiologist for a more specialized evaluation.

In summary, while Amlodipine is generally safe and effective for managing blood pressure and preventing myocardial ischemia, your ongoing symptoms warrant careful monitoring and open communication with your healthcare provider. It is essential to address any concerns you have about your medication and to ensure that your treatment plan aligns with your health needs. Regular follow-ups and a collaborative approach to your care will help ensure that you receive the best possible management for your heart health.

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