Muscle Twitches: Connection to ALS and Other Causes - Neurology

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The relationship between muscle twitching (spasms) and amyotrophic lateral sclerosis (ALS)?


Hello, Doctor.
I am 35 years old and started experiencing muscle twitches six months ago.
At that time, the frequency was low, and I didn't pay much attention to it.
However, for the past two weeks, I have been having muscle twitches every day, several times a day, lasting 3-5 seconds each time, which are now visible to the naked eye.
The most frequent area is the muscle below the thumb on my right palm (to the right of the life line).
Additionally, I occasionally experience twitching in my right thigh, left calf, and the sole of my left foot.
With a newborn child and being the primary breadwinner for my family, I am very concerned about my health.
I would like to ask about the relationship between these muscle twitches and amyotrophic lateral sclerosis (ALS).
1.
I read that muscle twitches without accompanying muscle weakness or atrophy are not a cause for concern.
Does this mean that in ALS, muscle weakness and muscle twitches occur "simultaneously"? In clinical practice, do muscle twitches in ALS occur before, after, or at the same time as muscle weakness?
2.
Could these twitches be due to cervical spine compression affecting the nerves? (I have a history of neck stiffness.) I am unsure if cervical spine compression could also cause twitching in the lower limbs.
3.
I work in the securities industry, which is high-stress.
Could stress or anxiety cause these twitches? I am concerned that the twitching in the "right upper palm" may not be solely stress-related.
4.
What is the purpose of arranging a nerve conduction study? Is it to confirm whether the nerves are being compressed? If it is confirmed that there is compression, can we conclude that the twitching is caused by nerve compression?
Thank you very much!

Max, 30~39 year old female. Ask Date: 2016/05/21

Dr. Gao Chunde reply Neurology


Amyotrophic lateral sclerosis (ALS) is characterized by the progressive loss of motor neurons, leading to a decrease in motor nerve function, muscle atrophy, and observable fasciculations.
Concurrently, or at some point before or after, there is no definitive timeline; however, the most significant symptoms are muscle weakness and atrophy.
Mild weakness or atrophy may sometimes only manifest as decreased dexterity.
As for muscle twitching, it can result from nerve hyperexcitability, stress, or certain foods, beverages, or medications, and is not exclusively indicative of denervation.
Therefore, after a thorough medical history and physical examination, physicians may arrange for electromyography (EMG) testing to confirm suspicions.
Nerve conduction studies can help rule out other neuropathies that are not related to ALS.

Reply Date: 2016/05/21

More Info


Muscle twitches, also known as fasciculations, can be concerning, especially when they become frequent or widespread. Your situation, where you have experienced muscle twitches for several months, raises valid questions about the potential connection to conditions like Amyotrophic Lateral Sclerosis (ALS) and other neurological issues. Let's address your concerns systematically.

1. Muscle Twitches and ALS: It is important to understand that muscle twitches alone do not indicate ALS. In ALS, muscle weakness and atrophy typically accompany fasciculations. The progression of ALS often involves the degeneration of motor neurons, leading to muscle weakness and wasting. Fasciculations can occur in ALS, but they are usually seen in conjunction with muscle weakness. Therefore, if you are not experiencing any muscle weakness or atrophy, it is less likely that your symptoms are indicative of ALS. In clinical practice, muscle weakness often precedes or occurs simultaneously with fasciculations in ALS patients.

2. Possible Causes of Muscle Twitches: Muscle twitches can arise from various causes, including benign fasciculation syndrome, stress, anxiety, or even overexertion. Given your history of stress from work and the recent changes in your life with a newborn, it is plausible that anxiety could contribute to muscle twitching. Stress can lead to increased muscle tension and irritability of the nerves, resulting in twitching. Additionally, cervical spine issues, such as a pinched nerve due to prolonged poor posture or "sleeping wrong," can also cause localized muscle twitching, although this is more commonly associated with pain or weakness in the affected area.

3. Neck Issues and Muscle Twitches: If you have a history of neck pain or "sleeping wrong," it is possible that cervical spine issues could contribute to your symptoms. Nerve compression in the cervical region can lead to muscle twitching in the upper extremities, and in some cases, it can affect the lower extremities as well. However, the relationship between neck issues and lower limb twitching is less direct and would typically involve more widespread neurological symptoms.

4. Role of Stress and Anxiety: Stress and anxiety can indeed manifest physically, leading to muscle twitches. The location of your twitching in the right palm could be related to localized muscle fatigue or tension rather than a serious underlying condition. It is essential to manage stress through relaxation techniques, exercise, or counseling, as these can help alleviate symptoms.

5. Purpose of Nerve Conduction Studies: Nerve conduction studies (NCS) are performed to assess the electrical conduction of nerves and can help identify any nerve damage or compression. If the results indicate nerve compression, it could explain the muscle twitching. However, it is crucial to interpret these results in conjunction with clinical findings and symptoms. If nerve compression is confirmed, it may suggest that your muscle twitches are related to this issue rather than a neurodegenerative condition.

In conclusion, while muscle twitches can be alarming, they are often benign, especially in the absence of muscle weakness or atrophy. It is essential to follow up with your healthcare provider for a thorough evaluation, including the nerve conduction studies you mentioned. They can provide a more accurate diagnosis based on your clinical presentation and test results. Additionally, managing stress and ensuring proper posture can significantly help reduce symptoms. If you have further concerns, do not hesitate to seek medical advice for peace of mind.

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