Can PRP Therapy Effectively Treat Ankle Cartilage Necrosis? - Orthopedics

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Can PRP therapy be used to treat ankle cartilage necrosis?


About two years ago, I experienced pain in my right ankle and went to the hospital for an examination.
The doctor diagnosed it as osteochondral necrosis, and since the condition did not require surgery, I was advised to wear an ankle brace and try self-healing.
I eventually recovered, but 1 to 2 months ago, the pain in my right ankle returned.
I went to the hospital again, and the doctor said the condition had relapsed.
This time, they suggested PRP therapy for treatment.
Is this feasible? To be honest, PRP therapy is quite expensive, so I would like to know if there are any other treatment options available.
Thank you.

Ms. Huang, 30~39 year old female. Ask Date: 2016/06/07

Dr. Shi Guozheng reply Orthopedics


Cartilage necrosis is a somewhat vague term that typically refers to cartilage wear and bone spur formation, which is characteristic of osteoarthritis.
In the second or third stage, administering PRP (platelet-rich plasma) may be effective, but the results can only last about nine months to a year.
If the arthritis progresses to the fourth stage, surgical intervention is necessary.
Initially, rehabilitation should be attempted, along with pharmacological treatment, and the use of an ankle brace is recommended to protect the joint.
It is also advised to avoid strenuous activities and to limit standing for long periods or walking long distances.

Reply Date: 2016/06/07

More Info


Platelet-Rich Plasma (PRP) therapy has gained popularity in recent years as a treatment option for various musculoskeletal conditions, including cartilage necrosis in the ankle. Your situation, where you have experienced a recurrence of pain due to cartilage necrosis, raises important considerations regarding the efficacy and appropriateness of PRP therapy.

PRP therapy involves extracting a small amount of your blood, processing it to concentrate the platelets, and then injecting this platelet-rich plasma into the affected area. The rationale behind this treatment is that platelets contain growth factors that can promote healing and tissue regeneration. In the context of cartilage necrosis, PRP may help stimulate the healing process of the damaged cartilage and reduce inflammation, potentially alleviating pain.

Research on the effectiveness of PRP for cartilage injuries is still evolving. Some studies suggest that PRP can provide pain relief and improve function in patients with osteoarthritis and cartilage damage, while other studies indicate mixed results. The variability in outcomes may be due to differences in the severity of the condition, the specific techniques used in PRP preparation, and individual patient factors.

In your case, since you have already experienced a recurrence of symptoms after an initial period of self-healing, PRP therapy could be a viable option to consider. However, it is essential to have a thorough discussion with your healthcare provider about the potential benefits and risks associated with PRP therapy, especially given the high costs involved. Your doctor may also consider other treatment modalities, such as physical therapy, corticosteroid injections, or hyaluronic acid injections, which may provide relief without the financial burden of PRP.

Physical therapy can be particularly beneficial in strengthening the muscles around the ankle, improving stability, and enhancing overall function. This conservative approach may help manage pain and prevent further deterioration of the cartilage. Additionally, lifestyle modifications, such as weight management and activity modification, can also play a crucial role in managing symptoms and preventing exacerbation of the condition.

If PRP therapy is pursued, it is important to set realistic expectations. While many patients report improvements, the degree of benefit can vary widely. Some may experience significant pain relief and improved function, while others may see minimal changes. It is also worth noting that PRP therapy is generally considered safe, but as with any medical procedure, there are potential risks, including infection, pain at the injection site, and allergic reactions.

In conclusion, PRP therapy may be a reasonable option for treating your ankle cartilage necrosis, especially if conservative measures have not provided sufficient relief. However, it is crucial to weigh the costs and benefits with your healthcare provider and explore all available treatment options. A comprehensive approach that includes physical therapy and lifestyle modifications may also enhance your recovery and overall well-being.

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