Chickenpox in Infants After BCG Vaccination - Pediatrics

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Infants develop chickenpox?


Hello doctor, my son is currently over five months old.
He received the BCG vaccine last Friday, and unexpectedly, he developed chickenpox a week later.
Is there any conflict between the BCG vaccine and chickenpox in his body? What should I be aware of? Thank you.

Wang, 20~29 year old female. Ask Date: 2016/07/16

Dr. Xiao Kaiwen reply Pediatrics


The BCG vaccine and varicella (chickenpox) do not conflict with each other.
Aspirin and other salicylate medications should not be used as antipyretics.
Complications of varicella include pneumonia, encephalitis, secondary bacterial infections, and sepsis.
Therefore, the dangerous signs to observe include: altered consciousness, persistent drowsiness, restlessness without fever, glazed eyes, seizures, persistent vomiting, blood-tinged sputum, apnea, rapid breathing without fever, difficulty breathing, retraction of the chest wall during inhalation, bradycardia, irregular heartbeat, inability to engage in normal activities, appearance of purpura on the skin, and cyanosis of the lips, fingers, and toes.
Antiviral medications for varicella can be taken as soon as possible at one's own expense.

Reply Date: 2016/07/16

More Info


When it comes to understanding the relationship between BCG vaccination and the occurrence of chickenpox in infants, it's important to clarify a few key points regarding both vaccinations and the diseases they protect against.

Firstly, the BCG vaccine (Bacillus Calmette-Guérin) is primarily used to protect against tuberculosis (TB). It is a live attenuated vaccine, meaning it contains a weakened form of the bacteria that causes TB. The vaccine is typically administered to infants shortly after birth, especially in countries where TB is prevalent. On the other hand, chickenpox (varicella) is caused by the varicella-zoster virus, which is also a live attenuated vaccine but is distinct from the BCG vaccine.

The occurrence of chickenpox after receiving the BCG vaccine is not directly related to the vaccine itself. The BCG vaccine does not provide any protection against chickenpox, nor does it interfere with the immune response to the varicella virus. Therefore, if your infant developed chickenpox a week after receiving the BCG vaccine, it is likely coincidental and not due to any interaction between the two vaccines.

In infants, chickenpox typically presents with an itchy rash that progresses from red spots to fluid-filled blisters, which eventually crust over. While chickenpox is generally a mild illness in healthy children, it can lead to complications, especially in very young infants or those with weakened immune systems. It is crucial to monitor your child for any signs of complications, such as a high fever, difficulty breathing, or signs of infection in the blisters.

Here are some important considerations and recommendations for managing chickenpox in your infant:
1. Symptom Management: Ensure your child is comfortable. You can use calamine lotion to soothe the itching and give your child antihistamines (as recommended by your pediatrician) to help alleviate discomfort. Keeping your child's nails trimmed can prevent scratching, which can lead to secondary infections.

2. Hydration: Ensure your child stays well-hydrated, especially if they have a fever. Offer plenty of fluids, such as water, diluted fruit juices, or oral rehydration solutions.

3. Isolation: Chickenpox is highly contagious. To prevent spreading the virus to others, keep your child at home and away from other children, especially those who are unvaccinated or have weakened immune systems, until all the blisters have crusted over.

4. Consult Your Pediatrician: If your child develops a high fever, has difficulty breathing, or shows any signs of severe illness, contact your pediatrician immediately. They may recommend antiviral medications if your child is at high risk for complications.

5. Vaccination Considerations: After your child recovers from chickenpox, they should still receive the varicella vaccine at the appropriate age (usually between 12-15 months) to ensure long-term immunity against chickenpox.

In summary, while the BCG vaccine and chickenpox are both live attenuated vaccines, they do not interact with each other. The development of chickenpox in your infant after receiving the BCG vaccine is likely coincidental. Focus on managing the symptoms of chickenpox and consult your pediatrician for personalized advice and care.

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