BCG Vaccine Reactions and Kawasaki Disease in Children - Pediatrics

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BCG vaccine issues


Hello, doctor.
When my child was about 2 years old, he had a cold, and I noticed that the area where he received the BCG vaccine was pink.
I can't remember if he had a fever for more than five days.
Later, during a routine check-up at the hospital, I asked the doctor, "Is it normal for his BCG site to look like this?" The doctor replied, "It's normal." However, I didn't follow up to ask if it could possibly be Kawasaki disease.
I would like to know if it's still possible for the BCG site to be pink at the age of 2.
If he has Kawasaki disease, will taking cold medicine help reduce the fever? Would it be necessary to take him for a cardiac ultrasound? Thank you.

Xiao Yu Ma, 30~39 year old female. Ask Date: 2017/10/19

Dr. Xiao Kaiwen reply Pediatrics


Without directly observing the appearance of the BCG scar and conducting a physical examination, it is difficult to determine if it is normal.
Kawasaki disease is an immune system issue with specific treatment methods; common cold medications typically do not reduce fever.
Therefore, if your child has a fever reduction, it is unlikely to be Kawasaki disease.

Reply Date: 2017/10/19

More Info


When it comes to understanding the reactions to the BCG vaccine (Bacillus Calmette-Guérin) and the potential implications for Kawasaki disease in children, it is essential to consider several factors. The BCG vaccine is primarily administered to protect against tuberculosis and is known to cause localized reactions at the injection site. These reactions can include redness, swelling, and tenderness, which may appear as a pink or red area on the skin. It is not uncommon for the injection site to remain pink for an extended period, especially in young children, and this is generally considered a normal response to the vaccine.

In your case, the pinkness observed at the BCG vaccination site when your child was around two years old is likely a typical reaction. The fact that the doctor deemed it normal during the check-up further supports this notion. However, it is important to differentiate between a normal vaccine reaction and symptoms that may indicate a more serious condition, such as Kawasaki disease.

Kawasaki disease is an acute vasculitis that primarily affects children and is characterized by prolonged fever (lasting more than five days), rash, conjunctivitis, changes in the lips and oral cavity, cervical lymphadenopathy, and palm or sole involvement. If your child had a fever exceeding five days along with other symptoms consistent with Kawasaki disease, it would warrant further investigation. However, if the only symptom was the localized reaction at the BCG site without any other systemic signs, it is less likely to be related to Kawasaki disease.

Regarding the use of antipyretics (fever-reducing medications) for Kawasaki disease, it is important to note that while these medications can help manage fever, they do not treat the underlying condition. Kawasaki disease requires specific treatment, typically with intravenous immunoglobulin (IVIG) and aspirin, to reduce the risk of coronary artery complications. Therefore, if your child were diagnosed with Kawasaki disease, simply administering cold medications would not be sufficient to address the condition.

As for the need for echocardiography (ultrasound of the heart), it is a standard procedure for children diagnosed with Kawasaki disease to assess for any potential heart involvement, particularly coronary artery aneurysms. This imaging is usually performed during the acute phase of the illness and may be repeated in follow-up visits to monitor heart health.

In summary, the pinkness at the BCG vaccination site is likely a normal reaction, especially if there were no accompanying symptoms of Kawasaki disease. If there are concerns about Kawasaki disease or if your child exhibits any unusual symptoms, it is crucial to consult a healthcare professional for a thorough evaluation. Regular follow-ups and monitoring are essential for children with a history of Kawasaki disease to ensure their heart health remains stable.

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