Pre-Marital Health Check: Elevated White Blood Cells in Semen - Urology

Share to:

Pre-marital health checkup


Hello, Doctor: I would like to ask a question.
I recently underwent a premarital health check, and the report indicated that there was a red flag in the semen analysis, specifically noting that my white blood cell count was slightly elevated (WBC: 1-3/HPF).
I would like to know if treatment is necessary if I do not have any symptoms.
Additionally, if I choose not to pursue treatment, could this lead to infertility issues for me and my fiancée regarding our future children? I apologize for my tendency to overthink, and I appreciate your help in clarifying these concerns! Thank you very much!

Jay, 30~39 year old female. Ask Date: 2016/08/09

Dr. Sun Hongshun reply Urology


Hello, 1-3 WBC/HPF refers to the presence of 1-3 white blood cells in a high-power field under a microscope.
Please clarify whether this is a semen analysis or a urine analysis.
Furthermore, regardless of whether it is semen or urine, both are expelled from the urethra, and the process may involve contact with the foreskin, which can lead to elevated values highlighted in red.
Since there are no symptoms, treatment is generally not necessary and it is unlikely to cause infertility.
However, if you are particularly cautious and still have concerns, you may consider consulting a urologist or retesting.
This is for your reference.

Reply Date: 2016/08/09

More Info


Elevated white blood cell (WBC) counts in semen, particularly when reported as 1-3 WBCs per high power field (HPF), can be a source of concern for many individuals undergoing pre-marital health checks. It’s important to understand the implications of this finding and how it relates to fertility and overall reproductive health.

Firstly, a WBC count of 1-3 per HPF in semen is generally considered to be within a borderline range. Normal semen analysis typically allows for some white blood cells, as they can be part of the immune response to potential infections or inflammation in the reproductive tract. However, significantly elevated WBC counts (usually considered as more than 1 million WBCs per mL) can indicate a condition known as leukocytospermia, which may be associated with infections or inflammation of the reproductive organs, such as prostatitis or epididymitis.

In your case, since you report no symptoms such as pain, discomfort, or any signs of infection (like fever or unusual discharge), it is likely that this mild elevation in WBCs may not be clinically significant. However, it is always prudent to consider the context of your overall health and any potential risk factors. If there is a history of urinary tract infections, sexually transmitted infections, or other reproductive health issues, further evaluation may be warranted.

Regarding the concern about fertility, mild elevations in WBCs in semen are not typically associated with infertility unless they are part of a broader issue affecting sperm quality. Studies have shown that high levels of leukocytes can negatively impact sperm motility and morphology, which could potentially affect fertility. However, with your current WBC count being relatively low, it is unlikely to pose a significant risk to your fertility or that of your future children.

If you and your fiancée are planning to conceive, it may be beneficial to have a follow-up semen analysis after a few months, especially if you remain concerned. This can help determine if the WBC count remains stable or if there are any changes that might warrant further investigation. Additionally, if you experience any new symptoms or changes in your health, it would be wise to consult with a healthcare provider.

In summary, while an elevated WBC count in semen can be a point of concern, your specific result of 1-3 WBCs per HPF is generally not alarming, especially in the absence of symptoms. It is advisable to maintain regular health check-ups and communicate openly with your healthcare provider about any concerns regarding fertility or reproductive health. If you remain anxious about this finding, discussing it further with a urologist or a reproductive health specialist could provide additional reassurance and guidance tailored to your specific situation.

Similar Q&A

Understanding Elevated Sperm White Blood Cells: Should You Be Concerned?

Hello Dr. Tsai: Recently, my fiancée and I underwent premarital health screening, and the report indicated that my semen white blood cell count is elevated, with a result of 1. This has caused me some concern, and I would like to ask you how serious this issue is. Should I be ove...


Dr. Cai Zhuorong reply Urology
The presence of white blood cells indicates a need to consider infection; however, different laboratories have varying rates of false positives. It is recommended to seek medical attention and undergo re-examination for confirmation.

[Read More] Understanding Elevated Sperm White Blood Cells: Should You Be Concerned?


Understanding Semen Analysis: Causes of Abnormal Sperm Morphology and WBC Levels

Hello, Director Du! I underwent a premarital check-up in November 2016, and all the reports were satisfactory. However, on May 11, 2019, I had a semen analysis, which revealed suboptimal sperm morphology and an elevated white blood cell (WBC) count. Could you please advise on the...


Dr. Du Shixi reply Urology
Hello: I only look at the quantity, motility, morphology, and the presence of white blood cells. However, the report states that it has liquefied, which may affect the accuracy of motility. The presence of white blood cells could indicate inflammation. These issues should be expl...

[Read More] Understanding Semen Analysis: Causes of Abnormal Sperm Morphology and WBC Levels


Understanding Abnormal Blood and Semen Test Results Before Pregnancy

Hello doctor, my husband and I underwent pre-pregnancy check-ups after our marriage. My report shows abnormal white blood cells: 5-10, negative for rubella, and negative for varicella antibodies. My husband's report indicates abnormal white blood cells in his semen. What do ...


Dr. Cao Guotao reply Obstetrics and Gynecology
Hello, pre-pregnancy check-up after marriage: German measles (rubella): negative, chickenpox antibodies: negative, vaccination is recommended. Your husband should see a urologist for examination. Wishing you good health.

[Read More] Understanding Abnormal Blood and Semen Test Results Before Pregnancy


Understanding Elevated WBC Levels in Semen Analysis: What to Do Next?

Hello Dr. Fu: I would like to ask about the semen analysis report from the hospital. The WBC (white blood cell) count is reported as 5-10 (with a reference range of 1-5). Is this considered elevated? If so, how should it be addressed? Which department should I consult? Additional...


Dr. Fu Shizhang reply Urology
If there are no symptoms, treatment may not be necessary, as elevated white blood cell counts could be due to inflammation, with the prostate being the most common site. If symptoms are present, it is recommended to visit an outpatient clinic for further examination.

[Read More] Understanding Elevated WBC Levels in Semen Analysis: What to Do Next?


Related FAQ