Concerns About Taking Stomach Medication During Early Pregnancy - Pharmacology

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I didn't know I was pregnant and took stomach medication?


Hello Dr.
Hou, I am currently five weeks pregnant.
A few days ago, I experienced stomach pain and unknowingly took three tablets of an over-the-counter antacid.
I am very concerned about the potential effects on the fetus.
Could you please take a look at the ingredients? Thank you.
Here are the components of the medication:
- Scopolamine-N-Butylbromide 2 mg
- Dicyclomine Hydrochloride 2 mg
- Chlordiazepoxide Hydrochloride 5 mg
- Sodium Copper Chlorophyllin 3 mg
- Hydroxide Aluminum Magnesium Co-Dried Gel 350 mg
- Magnesium Oxide 40 mg
- Synthetic Aluminum Silicate 60 mg

Ting, 20~29 year old female. Ask Date: 2016/08/18

Dr. Hou Fangmin reply Pharmacology


Hello: The following are the pregnancy categories for medications:
Category A: No risk of teratogenicity; these are safe drugs that have been studied in controlled trials in humans, with the lowest potential for fetal harm.

Category B: Animal studies have shown no risk to the fetus, but controlled studies in pregnant women have not been conducted.

Category C: Animal studies have shown adverse effects on the fetus, but controlled studies in pregnant women have not been conducted.
Medications in this category should only be used if the potential benefits to the fetus outweigh the potential risks based on clinical judgment.

Category D: There is evidence of human fetal risk; however, the use may be acceptable in certain situations where the benefits outweigh the risks.

Category X: Both animal and human studies have shown fetal abnormalities, indicating a risk to the fetus; these medications are absolutely contraindicated in pregnant women.

Scopolamine-N-Butylbromide 2mg is classified as Category C.

Dicyclomine Hydrochloride 2mg is classified as Category B.

Chlordiazepoxide Hydrochloride 5mg is classified as Category C.

Sodium Copper Chlorophyllin 3mg and Hydroxide Aluminum Magnesium Co-Dried Gel 350mg are classified as Category B.

Magnesium Oxide 40mg is classified as Category B.

Synthetic Aluminum Silicate 60mg is classified as Category B.

I have verified that the medications you are taking should not pose a problem; however, now that you know you are five weeks pregnant, it is crucial to be very cautious with any medications you use if you are feeling unwell.
Wishing you a happy motherhood and a healthy, joyful baby!

Reply Date: 2016/08/18

More Info


When it comes to taking medications during early pregnancy, particularly stomach medications, it is essential to understand the potential risks and benefits involved. You mentioned that you are currently five weeks pregnant and have taken over-the-counter stomach medications without knowing you were pregnant. Let's break down the components of the medication you took and their implications for fetal health.

1. Scopolamine-N-Butylbromide: This medication is an antispasmodic that is often used to relieve gastrointestinal spasms. While there is limited data on its use during pregnancy, it is generally classified as a Category C drug. This means that risk cannot be ruled out, and it should only be used if the potential benefits justify the potential risks to the fetus.

2. Dicyclomine Hydrochloride: Similar to scopolamine, dicyclomine is also an antispasmodic used for treating irritable bowel syndrome and other gastrointestinal disorders. It is classified as a Category C drug as well, indicating that animal reproduction studies have shown an adverse effect on the fetus, but there are no adequate and well-controlled studies in pregnant women. Therefore, it should be used cautiously.

3. Chlordiazepoxide Hydrochloride: This medication is a benzodiazepine that is sometimes used to treat anxiety and alcohol withdrawal. It is classified as a Category D drug, which means there is positive evidence of human fetal risk based on adverse reaction data. However, the benefits of treatment may outweigh the risks in certain situations. It is generally advised to avoid this medication during pregnancy, especially in the first trimester.

4. Sodium Copper Chlorophylline: This is a derivative of chlorophyll and is often used as a dietary supplement or for its deodorizing properties. There is limited information regarding its safety during pregnancy, but it is generally considered safe in food amounts.

5. Hydroxide Aluminum Magnesium Co-Dried Gel: This is an antacid that is commonly used to relieve heartburn and indigestion. It is generally considered safe during pregnancy, as it does not appear to pose a significant risk to the fetus.

6. Magnesium Oxide: This is also an antacid and is typically regarded as safe during pregnancy. It can help alleviate symptoms of indigestion and heartburn.

7. Synthetic Aluminum Silicate: This compound is used as an anti-caking agent and is generally considered safe during pregnancy.

Given the medications you have taken, the most concerning components are chlordiazepoxide and the antispasmodics (scopolamine and dicyclomine). While the risk of significant fetal harm from a single exposure is generally low, it is crucial to consult with your healthcare provider to discuss your specific situation. They can provide personalized advice based on your medical history and the specifics of your pregnancy.

In terms of early pregnancy symptoms, many women experience nausea and vomiting, commonly referred to as "morning sickness," which can occur at any time of the day. This symptom is not necessarily indicative of the baby's sex or any underlying issues. Hormonal changes during pregnancy can lead to various symptoms, and each pregnancy can be different. Some women may experience more severe symptoms in one pregnancy compared to another.

In conclusion, while the medications you took may pose some risks, the overall impact on fetal development will depend on various factors, including the timing of exposure and the specific dosages taken. It is always best to err on the side of caution and consult with your healthcare provider for further evaluation and guidance. They may recommend additional monitoring or alternative treatments to manage your symptoms safely during pregnancy.

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