Creatinine Levels and Kidney Health: A Patient's Inquiry - Internal Medicine

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Kidney issues and creatinine?


Hello Dr.
Wu,
I have a few questions that I hope you can help me with.
I am 60 years old, 175 cm tall, and weigh 72 kg, giving me a BMI of 23.5.
I have a habit of hiking every day.
My serum creatinine levels are 1.6 to 1.7 mg/dL, and my glomerular filtration rate (GFR) is 42 mL/min.
My urinalysis (pH, urine glucose, hematuria, and urine protein) has always been normal.
My cholesterol levels are at the upper limit of normal.
I have seen a doctor regarding my kidney issues, and I have been taking medication for six months (Captopril, Pentoxifylline, and Rosuvastatin).
However, my creatinine levels have not changed significantly after six months.
I would like to know if I should continue taking these medications, as I feel there has been no improvement, and I am concerned about the long-term effects on my liver and kidneys.
I would appreciate your guidance on this matter.
Thank you.

Li, 60~69 year old female. Ask Date: 2016/12/29

Dr. Wu Jiyu reply Internal Medicine


Hello, based on the information you provided, you have mild chronic kidney disease, classified as stage 3 (mild).
Patients with chronic kidney disease should indeed avoid nephrotoxic medications (such as nonsteroidal anti-inflammatory drugs), but not all medications adversely affect the kidneys or impose a burden on renal function.
The medication "Rosuvastatin" is primarily used for lipid control, and good lipid management helps reduce the incidence of cardiovascular diseases without impacting kidney function.
"Amlodipine" is a preferred antihypertensive medication for patients with kidney disease, and as long as there are no contraindications such as hyperkalemia or renal artery stenosis, its use not only effectively lowers blood pressure but also provides long-term protection for kidney function and reduces proteinuria.
"Lisinopril" also offers a certain degree of kidney function protection and does not negatively affect renal function.
However, individual circumstances vary, and the medications used may differ from person to person.
You may discuss your concerns with your attending physician, who can provide more detailed information.

Reply Date: 2016/12/29

More Info


Understanding creatinine levels and kidney health is crucial for managing and monitoring renal function, especially in patients with existing kidney concerns. In your case, with a creatinine level of 1.6 to 1.7 mg/dL and an estimated glomerular filtration rate (eGFR) of 42 mL/min, it indicates that you are experiencing some degree of chronic kidney disease (CKD). The normal range for creatinine is typically around 0.6 to 1.2 mg/dL for most adults, and an eGFR below 60 mL/min is considered indicative of CKD.

Your urine analysis results, which show normal pH, absence of glucose, blood, and protein, are encouraging. These results suggest that there is no significant proteinuria or hematuria, which are common indicators of kidney damage. However, the elevated creatinine levels and reduced eGFR indicate that your kidneys are not filtering waste effectively, which is a concern that needs to be addressed.

Regarding your current medications—Captopril, Pentoxifylline, and Rosuvastatin—these are commonly prescribed for managing hypertension, improving blood flow, and controlling cholesterol levels, respectively. Captopril, an ACE inhibitor, is particularly beneficial in protecting kidney function in patients with diabetes or hypertension, as it can help reduce the pressure in the glomeruli, thereby slowing the progression of kidney disease. Pentoxifylline can improve blood flow and reduce inflammation, while Rosuvastatin helps manage cholesterol levels, which is important for cardiovascular health.

It's understandable to be concerned about the long-term effects of these medications, especially regarding potential liver and kidney burden. However, the benefits of these medications often outweigh the risks, particularly when it comes to protecting kidney function and managing cardiovascular health. It is essential to have regular follow-ups with your healthcare provider to monitor your kidney function and adjust medications as necessary. If your creatinine levels remain stable and there are no signs of worsening kidney function, it may be appropriate to continue your current regimen.

If you feel that the medications are not providing any improvement or if you are experiencing side effects, it is crucial to discuss these concerns with your doctor. They may consider adjusting your treatment plan, which could include changing medications, dosages, or incorporating lifestyle modifications such as dietary changes, increased hydration, and regular exercise, which you are already practicing with your hiking routine.

In summary, while your current kidney function is a concern, the medications you are taking are aimed at managing your overall health and protecting your kidneys. Regular monitoring and open communication with your healthcare provider are essential to ensure that your treatment plan remains effective and safe. If you have any further questions or concerns, do not hesitate to reach out to your healthcare team for personalized advice and support.

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