Abnormal Creatinine Levels: What You Need to Know - Internal Medicine

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Creatinine level


Hello Doctor,
I recently received a notification regarding abnormal results from my health check-up.
My creatinine level in kidney function tests is 0.59, while both blood urea nitrogen and uric acid levels are normal.
What should I be aware of? Thank you for taking the time to respond.

Eva, 10~19 year old female. Ask Date: 2017/03/01

Dr. Wu Hongjie reply Internal Medicine


Dear Sender,
Many factors can interfere with changes in creatinine levels, such as kidney function and muscle mass.
Generally speaking, elevated creatinine levels are more concerning, while low levels are typically indicative of reduced muscle mass.
It is advisable for individuals who are underweight to increase their muscle mass through a balanced protein diet and regular exercise.
Wishing you health and safety.

Reply Date: 2017/03/01

More Info


Understanding abnormal creatinine levels is crucial for assessing kidney function and overall health. Creatinine is a waste product generated from muscle metabolism, and it is typically filtered out of the blood by the kidneys. Therefore, measuring creatinine levels can provide valuable insights into how well your kidneys are functioning.

In your case, a creatinine level of 0.59 mg/dL is considered low, as the normal range for adults is typically between 0.6 to 1.2 mg/dL. While low creatinine levels are less common than elevated levels, they can occur for several reasons. Here are some key points to consider:
1. Hydration Status: Low creatinine levels can sometimes indicate that you are well-hydrated. If you have been drinking plenty of fluids, your kidneys may be filtering out creatinine more effectively, leading to lower levels in your blood.

2. Muscle Mass: Creatinine levels are influenced by muscle mass. Individuals with lower muscle mass, such as the elderly or those who are physically inactive, may have lower creatinine levels. If you have a smaller body frame or have recently lost weight, this could explain the low reading.

3. Dietary Factors: A diet low in protein can also lead to lower creatinine levels. If you have recently changed your diet to include less meat or protein-rich foods, this might be a contributing factor.

4. Kidney Function: While low creatinine levels are generally not a cause for concern, it is essential to consider them in the context of your overall kidney function. Since your blood urea nitrogen (BUN) and uric acid levels are normal, this suggests that your kidneys are functioning adequately. However, it is always wise to monitor kidney function over time, especially if you have risk factors for kidney disease.

5. Underlying Health Conditions: Certain medical conditions, such as liver disease or malnutrition, can also lead to low creatinine levels. If you have any underlying health issues, it is essential to discuss these with your healthcare provider.

6. Follow-Up: It is advisable to have regular follow-up tests to monitor your kidney function, especially if you have any risk factors such as diabetes, hypertension, or a family history of kidney disease. Your healthcare provider may recommend additional tests, such as a creatinine clearance test or a urine test, to further evaluate your kidney function.

In conclusion, while a creatinine level of 0.59 mg/dL is low, it is not necessarily alarming, especially in the context of normal BUN and uric acid levels. However, it is essential to consider your overall health, hydration status, muscle mass, and dietary habits. If you have any concerns or experience symptoms such as fatigue, swelling, or changes in urination, it is crucial to consult your healthcare provider for a comprehensive evaluation and personalized advice. Regular monitoring and open communication with your healthcare team will help ensure that your kidney health remains a priority.

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