Elevated Creatinine Levels: Causes and Concerns - Internal Medicine

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Creatinine issues?


The health examination report indicates that there are no signs of hematuria or proteinuria, and the blood urea nitrogen level is normal.
However, the creatinine level is 1.34 mg/dL.
The doctor advised to follow up in three months.
Given that I had surgery for a fracture in early April and continued to take anti-inflammatory and pain medications for a month after discharge, could this have caused the abnormal kidney function? There is no family history of hypertension or diabetes.
Thank you!

A Fei, 20~29 year old female. Ask Date: 2010/08/27

Dr. Yang Zhongwei reply Internal Medicine


Most medical centers have a normal serum creatinine level up to 1.4 mg/dL.
If urine tests show no proteinuria or hematuria and serum creatinine is less than 1.4 mg/dL, we consider kidney function to be normal.
To assess whether both kidneys are functioning properly, an ultrasound examination is necessary.
Additionally, it's important to note that certain over-the-counter pain medications can be harmful to the kidneys.

Reply Date: 2010/08/27

More Info


Elevated creatinine levels can be a concern as they may indicate impaired kidney function. In your case, a creatinine level of 1.34 mg/dL is slightly above the normal range, which typically falls between 0.6 to 1.2 mg/dL for most adults. However, it's important to interpret this value in the context of your overall health, medical history, and any recent medications or treatments you may have undergone.

Creatinine is a waste product produced from muscle metabolism and is usually filtered out of the blood by the kidneys. When kidney function declines, creatinine levels in the blood can rise. There are several potential causes for elevated creatinine levels, including:
1. Dehydration: Insufficient fluid intake can lead to concentrated blood and higher creatinine levels.

2. Acute Kidney Injury (AKI): This can occur due to various factors, including medications, infections, or reduced blood flow to the kidneys.

3. Chronic Kidney Disease (CKD): This is a long-term condition that can result from various underlying health issues, such as hypertension or diabetes, although you mentioned that there is no family history of these conditions.

4. Medications: Certain medications, especially nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen, can affect kidney function, particularly when taken over an extended period or in higher doses. Since you mentioned taking anti-inflammatory pain medications after your surgery, this could potentially contribute to your elevated creatinine levels.

Given that you had a recent surgery and were on medication, it is plausible that these factors could have temporarily impacted your kidney function. The fact that your blood urea nitrogen (BUN) levels are normal and there are no signs of protein or blood in your urine is reassuring. These findings suggest that your kidneys may still be functioning relatively well, but monitoring is essential.

Your doctor’s recommendation to recheck your creatinine levels in three months is appropriate. This follow-up will help determine if the elevated creatinine is a transient issue related to your recent surgery and medication use or if it indicates a more chronic condition. In the meantime, consider the following:
- Hydration: Ensure you are drinking enough fluids, as dehydration can exacerbate kidney issues.

- Medication Review: Discuss with your healthcare provider any medications you are taking, especially NSAIDs, and consider alternatives if necessary.

- Dietary Considerations: A balanced diet low in sodium and protein can help reduce the workload on your kidneys.

- Regular Monitoring: Keep track of any symptoms such as fatigue, swelling, or changes in urination, and report these to your doctor.

In conclusion, while an elevated creatinine level can be concerning, it is essential to consider the broader context of your health and any recent medical interventions. Regular follow-up and communication with your healthcare provider will be crucial in managing your kidney health effectively.

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