Elevated Creatinine Levels: Causes and Concerns - Internal Medicine

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Elevated creatinine levels?


Hello, doctor.
This year, during my health check-up, my kidney function test showed a creatinine level of 1.5 and a uric acid level of 4.31.
Last year, my creatinine level was 1.4 and my uric acid level was 5.3.
My BMI has been 22 for both years.
I have a regular exercise routine and consider my diet to be normal (I eat vegetables and fruits, but I do consume a bit more meat...).
I also follow a high-protein diet, with protein intake approximately 1.5 times my body weight.
I have read various articles and watched many related videos that suggest this level of intake should not place a significant burden on the kidneys.
However, seeing the elevated values has made me concerned.
I would appreciate your clarification on this matter.

GG Gongchengshi, 20~29 year old female. Ask Date: 2017/09/14

Dr. Wu Hongjie reply Internal Medicine


Hello, regarding your elevated creatinine levels, it is recommended that you see a nephrologist for further examination and follow-up.
Since your uric acid levels are normal, the cause of the renal dysfunction may require additional urine tests and blood tests to determine whether it is due to some systemic disease or intrinsic kidney pathology.
This should not be particularly related to your dietary preferences.
Please visit a hospital for further evaluation.
Wishing you safety and health.
Sincerely, Dr.
Wu Hong-Jie, Director of Nephrology, Taoyuan General Hospital, Ministry of Health and Welfare.

Reply Date: 2017/09/14

More Info


Elevated creatinine levels can be a cause for concern, especially when they are above the normal range. Normal creatinine levels typically range from about 0.6 to 1.2 mg/dL, depending on various factors including age, sex, and muscle mass. Your reported levels of 1.5 mg/dL and 1.4 mg/dL indicate a mild elevation, which can be influenced by several factors.

Firstly, it's important to understand that creatinine is a waste product generated from muscle metabolism and is usually excreted by the kidneys. Elevated levels can suggest that the kidneys are not functioning optimally. However, there are several reasons why creatinine levels might be elevated, and not all of them indicate kidney disease.

1. Muscle Mass: Since you mentioned that you have a fitness routine and consume a high-protein diet, it's possible that your elevated creatinine levels are related to increased muscle mass and protein intake. Individuals with higher muscle mass may naturally have higher creatinine levels.
2. Hydration Status: Dehydration can lead to elevated creatinine levels. If you are not adequately hydrated, your kidneys may not be able to filter waste products effectively, leading to higher creatinine readings.
3. Diet: While you mentioned that your diet includes a lot of vegetables and fruits, a high-protein diet can sometimes put additional strain on the kidneys, especially if there is an underlying kidney issue. However, for healthy individuals with normal kidney function, a high-protein diet is generally considered safe.

4. Kidney Function: It's essential to consider other kidney function tests, such as blood urea nitrogen (BUN) and the estimated glomerular filtration rate (eGFR). These tests can provide a more comprehensive picture of kidney health. An eGFR below 60 mL/min/1.73m² for three months or more is a sign of chronic kidney disease.

5. Other Medical Conditions: Conditions such as diabetes, hypertension, or urinary tract obstruction can also lead to elevated creatinine levels. If you have any of these conditions, they could be contributing to your elevated levels.

Given your concerns, it would be prudent to consult with a healthcare provider who can evaluate your overall kidney function and health. They may recommend further testing, such as a urinalysis, imaging studies, or even a referral to a nephrologist if necessary.
In the meantime, here are some general recommendations to help maintain kidney health:
- Stay Hydrated: Ensure you are drinking enough fluids throughout the day, especially if you are active and sweating.

- Monitor Protein Intake: While protein is essential for muscle repair and growth, excessive intake may not be necessary for everyone. Consider discussing your dietary needs with a nutritionist.

- Regular Check-ups: Keep up with regular health check-ups to monitor your kidney function and overall health.

- Manage Blood Pressure and Blood Sugar: If you have any risk factors for kidney disease, such as hypertension or diabetes, managing these conditions is crucial.

In summary, while elevated creatinine levels can indicate potential kidney issues, they can also be influenced by factors such as muscle mass, hydration, and diet. A thorough evaluation by a healthcare professional will help clarify the situation and determine if any action is needed.

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