Chlamydia Testing and Treatment: Your Concerns Addressed - Urology

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Hello, doctor.
Recently, I suspected an infection with Chlamydia and visited a urologist.
However, the doctor said I had no symptoms and mentioned that as long as urination is not painful, there is no issue.
Still, I was not reassured and went to a laboratory for testing.
The results are as follows:
1.
Chlamydia-DNA: Negative
2.
Anti-Chlamydia IgG: 0.84 (Is normal less than 0.8?)
3.
Anti-Chlamydia IgA: 5.65 (+) (Is normal less than 0.8? Is this too high?)
4.
Anti-Chlamydia IgM: 0.56 (-)
The laboratory informed me that I might still be infected.
Doctor, do I have any unresolved infection? The urologist treated me like I was crazy, believing that these tests are meaningless and that pain during urination is necessary for a diagnosis.
However, I do not experience pain while urinating, but occasionally I feel a slight pain in the urethra from the base of the glans to the urethral opening, about 2-3 times a day.

Additionally, I have been diagnosed with varicocele.
Could this condition cause the symptoms mentioned above (besides the occasional feeling of heaviness in the testicles, aching pain, and discomfort in the groin)? I read on some gynecological clinic websites that a positive IgA indicates an active infection, suggesting that I am not cured.
For example, this website: http://www.anantainan.com/column_view_10.html.
Should I consider self-medicating and testing the treatment's effectiveness at the laboratory myself? I apologize for the lengthy message.

Xiao Chen, 30~39 year old female. Ask Date: 2017/04/03

Dr. Xu Wencang reply Urology


Antibodies can potentially be present in various parts of the body, not just the urethra.
After a period of treatment, follow-up is necessary, as chronic inflammation can be latent.
Maintaining a normal lifestyle and boosting immunity may also lead to gradual improvement.
Please return for a follow-up appointment for the physician to reassess.

Reply Date: 2017/04/03

More Info


Understanding Chlamydia testing and treatment can be quite complex, especially when interpreting test results and correlating them with symptoms. Let's break down your concerns regarding the Chlamydia test results and the implications for your health.


Test Results Interpretation
1. Chlamydia-DNA Negative: This result indicates that there is no detectable Chlamydia DNA in your urine, which is a strong indicator that you do not have an active Chlamydia infection. This is a reassuring result.

2. Anti-Chlamydia IgG 0.84: IgG antibodies typically indicate past exposure to Chlamydia. A result of 0.84 is borderline; however, it is generally considered negative if the cutoff is below 0.8. This suggests that you may have been exposed to Chlamydia at some point, but it does not indicate an active infection.

3. Anti-Chlamydia IgA 5.65 (+): IgA antibodies can indicate a current or recent infection, but they are not as commonly used for diagnosing Chlamydia as IgG and IgM. A result of 5.65 is significantly elevated, which could suggest an ongoing immune response to Chlamydia. However, the interpretation of IgA levels can vary, and it is essential to correlate this with clinical symptoms and other test results.

4. Anti-Chlamydia IgM 0.56 (-): IgM antibodies typically indicate a recent infection. A negative result here suggests that you do not have a recent Chlamydia infection.


Symptoms and Concerns
You mentioned experiencing mild pain in the urethra and glans, which can be concerning. While the absence of pain during urination is a good sign, the discomfort you describe could be due to several factors, including:
- Chronic Inflammation: Sometimes, even after an infection has cleared, inflammation can persist, leading to discomfort.

- Other Infections: Other sexually transmitted infections (STIs) or urinary tract infections (UTIs) could cause similar symptoms.

- Varicocele: The diagnosis of varicocele (enlarged veins in the scrotum) can lead to discomfort and may contribute to testicular pain and a feeling of heaviness. However, it is less likely to cause urethral pain.


Should You Self-Treat?
Self-treatment is not advisable. It is crucial to consult with a healthcare provider before starting any medication. Misdiagnosing your condition or self-medicating can lead to complications or worsening of your symptoms.

Recommendations
1. Follow-Up with a Specialist: Since you have ongoing symptoms, consider seeking a second opinion from a urologist or an infectious disease specialist. They can provide a more comprehensive evaluation and possibly recommend further testing.

2. Discuss Your Concerns: Bring your test results and symptoms to your healthcare provider's attention. Explain your concerns about the IgA result and the discomfort you are experiencing.

3. Avoid Self-Medication: Do not purchase antibiotics or other medications without a prescription. This can lead to antibiotic resistance and may complicate your condition.

4. Monitor Symptoms: Keep track of your symptoms, including any changes in pain or discomfort, and report these to your healthcare provider.


Conclusion
In summary, while your Chlamydia-DNA test is negative, the elevated IgA level warrants further investigation, especially in light of your symptoms. It is essential to work closely with a healthcare provider to ensure proper diagnosis and treatment. Avoid self-treatment and seek professional guidance to address your concerns effectively.

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