Managing Pain and Inflammation in Ankylosing Spondylitis: A Patient's Journey - Internal Medicine

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Immune system ~ Swelling and pain in the fourth toe of the left foot?


Hello Doctor: My wife has a family history of ankylosing spondylitis.
She previously experienced an episode of iritis.
After a miscarriage last October, her left fourth toe started to swell and hurt at the end of October, and it has been six months since then.
Currently, she takes two immunomodulatory medications daily, along with steroids and anti-inflammatory drugs on an alternating schedule.
However, if she does not take the steroids and anti-inflammatories, the swelling and pain return.
I would like to ask the doctor if this condition can only be managed with continuous medication.
After all, long-term use of steroids and anti-inflammatory drugs is not good for the body.
Thank you.

Xiang, 30~39 year old female. Ask Date: 2017/05/04

Dr. Gao Jiankai reply Internal Medicine


Hello, thank you for your message.
Regarding the swelling and pain in your toes, please continue your medication, as this type of swelling and pain requires a longer treatment time and may need some patience.
As for the corticosteroids, you can discuss with your physician whether it is possible to gradually taper off the medication.
Corticosteroids play a relatively minor role in ankylosing spondylitis and can be discontinued earlier.
Best regards from the Allergy, Immunology, and Rheumatology Department of Changhua Hospital, Ministry of Health and Welfare.

Reply Date: 2017/05/04

More Info


Managing pain and inflammation in Ankylosing Spondylitis (AS) can be a complex and challenging journey, especially when considering the long-term implications of medication use. Your situation, particularly with a family history of AS and previous episodes of iritis, highlights the need for a comprehensive approach to treatment.

Ankylosing Spondylitis is a type of inflammatory arthritis that primarily affects the spine and can lead to severe, chronic pain and discomfort. The condition is often associated with inflammation in other areas of the body, such as the eyes (as you have experienced with iritis) and peripheral joints, which can lead to symptoms like swelling and pain in the toes or other extremities.

From your description, it seems that you are currently managing your symptoms with a combination of immunomodulatory drugs, corticosteroids, and anti-inflammatory medications. While these medications can be effective in controlling inflammation and pain, they do come with potential side effects, especially when used long-term. Corticosteroids, for example, can lead to weight gain, osteoporosis, and increased risk of infections, among other issues.

Here are some strategies and considerations that may help you manage your condition more effectively:
1. Medication Management: It’s crucial to have an open dialogue with your healthcare provider about your medication regimen. If you find that you are reliant on corticosteroids and anti-inflammatory medications to manage your symptoms, discuss the possibility of adjusting your treatment plan. There may be alternative medications, such as Disease-Modifying Anti-Rheumatic Drugs (DMARDs) or biologics, that can help manage your symptoms with potentially fewer side effects.

2. Physical Therapy: Engaging in a regular physical therapy program can be beneficial. A physical therapist can design a personalized exercise regimen that focuses on improving flexibility, strength, and posture, which can help alleviate pain and improve mobility. Exercises like swimming or yoga can be particularly helpful for maintaining joint function and reducing stiffness.

3. Lifestyle Modifications: Incorporating lifestyle changes can also play a significant role in managing AS. This includes maintaining a healthy diet rich in anti-inflammatory foods (like fruits, vegetables, whole grains, and omega-3 fatty acids), staying hydrated, and avoiding smoking and excessive alcohol consumption. Regular physical activity is essential, but it’s important to find a balance that works for your body.

4. Pain Management Techniques: In addition to medication, consider exploring non-pharmacological pain management techniques. This can include heat and cold therapy, acupuncture, or mindfulness and relaxation techniques, which can help reduce stress and improve your overall well-being.

5. Regular Monitoring: Given the chronic nature of AS, regular follow-ups with your rheumatologist are essential. They can monitor your disease progression and adjust your treatment plan as necessary. Blood tests and imaging studies can help assess inflammation levels and joint health.

6. Support Systems: Connecting with support groups or communities of individuals with AS can provide emotional support and practical advice. Sharing experiences with others who understand your challenges can be incredibly beneficial.

In conclusion, while medication is a critical component of managing Ankylosing Spondylitis, it is not the only strategy. A holistic approach that includes physical therapy, lifestyle modifications, and alternative pain management techniques can help you achieve better control over your symptoms and improve your quality of life. Always consult with your healthcare provider before making any changes to your treatment plan to ensure that it aligns with your specific health needs.

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