Lymph Node Issues in Lymphoma: Key Questions Answered - Oncology

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Lymph Node Issues - Follow-up Questions


Thank you for your previous response, Doctor.
I have a question to ask.
You mentioned that removing a lymph node can only confirm whether that specific node is problematic.
However, another doctor told me that lymphoma is systemic, so it doesn't matter which node is removed (how accurate is this?).
Previously, I had swollen lymph nodes throughout my body, and the doctor advised against removing the lymph nodes in my neck due to the abundance of blood vessels, suggesting instead to remove those in the groin.
How can we determine if the numerous swollen lymph nodes throughout my body are problematic? Currently, I still have several lymph nodes larger than one centimeter, but the doctors do not recommend removal.
Additionally, how reliable is positron emission tomography (PET) in confirming the presence of lymphoma? Thank you.

Xiao Cheng, 20~29 year old female. Ask Date: 2017/05/17

Dr. Chen Yunfang reply Oncology


Hello:
1.
"Seeing is believing" is 100% certain, while "based on experience" is not necessarily so.

2.
The same issue is a matter of probability; the best diagnostic method would be to excise all lymph nodes throughout the body, regardless of size, and send them to pathology for microscopic examination one by one.
However, is it feasible to have over 20 surgical wounds all over your body? That would leave you with no intact skin!
3.
Is it not recommended to excise? Is it because the size has not changed over months or years?
4.
Positron Emission Tomography (PET) scans are only covered by health insurance after a lymphoma diagnosis is confirmed (while the reliability is high, it is not 100%; generally, it may only be about 80%).
Since you currently have no evidence, I do not recommend you undergo this test.
Firstly, it would require an out-of-pocket expense of 36,000 NTD, and secondly, PET scans are not applicable for many cancers and cannot detect them (it is not an all-purpose examination!).
Thank you for your understanding!

Reply Date: 2017/05/17

More Info


Understanding lymph node issues, particularly in the context of lymphoma, can be quite complex and often raises many questions. Based on the information provided and the context of your concerns, let's delve into the key aspects of lymph node evaluation, the implications of lymphadenopathy, and the diagnostic methods available.


Lymph Node Evaluation and Lymphoma
Lymphoma is indeed a systemic disease, meaning it can affect multiple lymph nodes throughout the body. When a lymph node is biopsied or surgically removed, the pathologist can only assess the tissue from that specific node. This means that while the removed lymph node may be free of malignancy, it does not guarantee that other lymph nodes or areas of the body are also free from lymphoma. This is why it is crucial to have a comprehensive evaluation if there are multiple enlarged lymph nodes.


Why Some Lymph Nodes Are Not Removed
Your doctor’s recommendation to avoid removing certain lymph nodes, such as those in the neck due to their proximity to major blood vessels, is a common practice. The risks associated with surgery, including bleeding and nerve damage, often outweigh the benefits if the lymph nodes are not significantly suspicious for malignancy. In cases where lymph nodes are enlarged but not exhibiting characteristics of malignancy (such as being hard, fixed, or rapidly enlarging), doctors may opt for observation rather than invasive procedures.


Monitoring Enlarged Lymph Nodes
If you have multiple lymph nodes larger than one centimeter, it is essential to monitor them closely. The size alone does not determine malignancy; other factors such as consistency, mobility, and associated symptoms (like fever, night sweats, or weight loss) are also considered. Regular follow-ups with imaging studies or physical examinations can help track any changes in these nodes.


The Role of Imaging Studies
Positron Emission Tomography (PET) scans are often used in the evaluation of lymphoma. They are particularly useful because they can show areas of increased metabolic activity, which may indicate the presence of lymphoma. However, while PET scans are highly sensitive, they are not infallible. False positives can occur, and benign conditions can also show increased uptake. Therefore, the results of a PET scan should always be interpreted in conjunction with clinical findings and other diagnostic tests.


Conclusion
In summary, while the removal of a lymph node can provide valuable information, it does not rule out the possibility of lymphoma elsewhere in the body. The decision to monitor rather than remove additional lymph nodes is often based on a careful assessment of risks versus benefits. Regular follow-ups and imaging studies, particularly PET scans, can help in monitoring the situation. If you have concerns about the status of your lymph nodes or the possibility of lymphoma, it is crucial to maintain open communication with your healthcare provider. They can provide personalized recommendations based on your specific situation and medical history.

If you notice any changes in your lymph nodes, such as increased size, pain, or new symptoms, it is essential to report these to your doctor promptly. Early detection and intervention are key in managing any potential issues related to lymphoma or other lymphatic conditions.

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