Lymph Node Issues: Insights on Biopsy Results and Cancer Concerns - Oncology

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Cervical lymphadenopathy?


Hello doctor, I would like to ask about the lymph nodes in my left occipital and left cervical regions.
The lymph node in the left occipital area is approximately 1 cm and was discovered in September 2020.
Ultrasounds conducted in September 2020 and January 2021 indicated that there was no change in size or characteristics (the report stated: Smooth Marginated / Uniform hypoechoic cortex / Thin echogenic hilum / No calcification / No cystic component / No surrounding perinodal reactions / No overlying dermal thickening).
Additionally, in December 2020, I experienced discomfort in my throat, and an ultrasound in January 2021 reported the lymph node in the left cervical area to be 1.4 cm (the report stated: Smooth Marginated / Uniform hypoechoic cortex / Thin echogenic hilum / No calcification / No cystic component / No surrounding perinodal reactions / No overlying dermal thickening).
The left cervical lymph node has reduced in size after taking medication.
Over the past six months, I have undergone three nasopharyngoscopies, all of which showed no issues.
Both lymph nodes recently underwent fine needle aspiration (ultrasound-guided FNA) and blood tests (EBV, ESR, LDH).
The blood test results have not yet come back, but the doctor informed me that the FNA report indicated no cancer cells were found.
If there were metastatic cancer or lymphoma, should cancer cells have been detected in the fine needle aspiration? Additionally, should I still be concerned? Thank you very much.

Xu, 30~39 year old female. Ask Date: 2021/01/25

Dr. Chen Sirong reply Oncology


1.
The left occipital lymph nodes have not changed, so monitoring should suffice as long as they do not increase in size.

2.
The left cervical lymph nodes have decreased in size, which likely indicates that it is not cancer.

3.
If there is metastatic cancer or lymphoma, fine needle aspiration should typically reveal cancer cells.
A: If you are still concerned, surgical removal may be necessary.
However, generally speaking, as long as the lymph nodes do not grow, it is not cancer, as cancer usually continues to grow.

4.
Additionally, is there any need for further concern? Continue monitoring, and consider seeing an ENT specialist if you have a cold for further evaluation.
Keep monitoring without worry.

Wishing you a Happy New Year!

Reply Date: 2021/01/25

More Info


When it comes to lymph nodes and potential cancer concerns, understanding the results of imaging studies and biopsies is crucial. Based on your description, you have lymph nodes in the left occipital and cervical regions that have been monitored over time with ultrasound examinations. The findings indicate that these lymph nodes have remained stable in size and appearance, which is generally a reassuring sign.

The characteristics of the lymph nodes you mentioned—smooth margins, uniform hypoechoic cortex, thin echogenic hilum, and the absence of calcification, cystic components, surrounding perinodal reactions, or overlying dermal thickening—are typically associated with benign lymphadenopathy. These features suggest that the lymph nodes are reactive rather than malignant. Reactive lymph nodes can enlarge in response to infections, inflammation, or other non-cancerous conditions.

You also mentioned that you underwent fine needle aspiration (FNA) biopsy of the lymph nodes, and the report indicated no cancer cells were found. This is a significant piece of information. In cases of metastatic cancer or lymphatic malignancies, FNA biopsies are often effective in detecting malignant cells. If cancer were present, it is likely that the biopsy would have revealed abnormal cells. However, it is important to note that no diagnostic test is perfect, and there can be false negatives, especially if the sampling did not capture the malignant cells.

Regarding your concerns about whether you should continue to worry about the lymph nodes, the stability of their size and the negative FNA results are encouraging. It is common for healthcare providers to recommend follow-up imaging or monitoring rather than immediate intervention when lymph nodes exhibit benign characteristics and there is no evidence of malignancy.

In terms of your blood tests, such as EBV (Epstein-Barr Virus), ESR (Erythrocyte Sedimentation Rate), and LDH (Lactate Dehydrogenase), these can provide additional context. Elevated levels of LDH, for example, can sometimes indicate malignancy, but they can also be elevated in benign conditions. EBV can be associated with certain lymphoproliferative disorders, but a positive result does not necessarily mean cancer is present.

In conclusion, based on the information provided, the findings from your ultrasounds and FNA biopsy suggest that the lymph nodes are likely benign. Continuous monitoring is a reasonable approach, especially given the lack of significant changes over time. It is essential to maintain open communication with your healthcare provider, who can guide you on the appropriate follow-up and any further investigations if necessary. If you experience new symptoms or changes in your health, be sure to report these to your doctor promptly. Regular check-ups and monitoring will help ensure that any potential issues are addressed early.

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