Identifying Drug Allergies: Swelling After Medication for Sore Throat - Pharmacology

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Drug allergy


After experiencing a sore throat and visiting a doctor, I developed swelling of the eyelids and lips on the third day after taking the prescribed medication.
Could you please advise which of the following medications I might be allergic to? 1.
VOREN 50mg (DICLOFENAC SODIUM) 2.
TNYH (oxathazaune) 3.
UNIFRADINE 500mg (CEPHRADINE) 4.
LYSOZYME (MILISHER) Thank you for your assistance, pharmacist.

Wang, 30~39 year old female. Ask Date: 2017/06/12

Dr. Chen Yuemei reply Pharmacology


Hello: Based on the type of allergy you have, it falls under angioedema.
The medications you are taking that may cause this type of allergic reaction are Voren (used for anti-inflammatory, analgesic, and antipyretic purposes, classified as an NSAID) and Unifradine (an antibiotic, classified as a Cephalosporin).
Have you had any previous experiences with drug allergies? You may want to consult your physician or pharmacist to further understand your past medication records in order to clarify which medication you are allergic to.

Reply Date: 2017/06/12

More Info


When experiencing swelling of the eyelids and lips after taking medication for a sore throat, it is crucial to consider the possibility of an allergic reaction to one of the prescribed drugs. Allergic reactions can manifest in various ways, including swelling, hives, rashes, and in severe cases, anaphylaxis. In your case, the swelling occurring three days after starting the medication suggests that it could be an allergic response to one of the drugs you were prescribed.
Let’s analyze the medications you mentioned:
1. VOREN 50mg (Diclofenac Sodium): This is a non-steroidal anti-inflammatory drug (NSAID) commonly used to relieve pain and inflammation. Allergic reactions to NSAIDs can occur, and symptoms may include swelling, rash, or gastrointestinal issues. If you have a history of allergies to other NSAIDs or aspirin, you may be at a higher risk for an allergic reaction to Diclofenac.

2. TNYH (Oxathazaune): This medication is less commonly known, but it is important to note that any drug can potentially cause an allergic reaction. If you have not taken this medication before, it is possible that your body may react to it.

3. UNIFRADINE 500mg (Cephradine): This is a cephalosporin antibiotic. Allergies to cephalosporins can occur, especially in individuals who are allergic to penicillin. Symptoms of an allergic reaction can include swelling, rash, and difficulty breathing. If you have a known allergy to penicillin, there is a chance you could also be allergic to cephalosporins like Cephradine.

4. LYSOZYME (Milisher): This is an enzyme that has antibacterial properties and is often used in throat lozenges or sprays. Allergic reactions to lysozyme are rare, but they can occur. Symptoms may include localized swelling or more generalized allergic reactions.

Given the information, it is essential to consider the timing and nature of your symptoms. Swelling of the eyelids and lips could indicate an allergic reaction, and the most likely candidates among the medications are Diclofenac and Cephradine, especially if you have a history of allergies to NSAIDs or penicillin.

Recommendations:
- Immediate Action: If the swelling is significant or accompanied by other symptoms such as difficulty breathing, hives, or swelling of the throat, seek emergency medical attention immediately, as this could indicate a severe allergic reaction (anaphylaxis).

- Consult Your Doctor: Inform your healthcare provider about the swelling and any other symptoms you may be experiencing. They may recommend stopping the medication and possibly prescribing an alternative treatment for your sore throat.

- Allergy Testing: If you suspect an allergy, your doctor may refer you to an allergist for testing to determine which specific medication you are allergic to.

In summary, while any of the medications could potentially cause an allergic reaction, Diclofenac and Cephradine are the most likely candidates based on the symptoms you described. It is crucial to communicate with your healthcare provider about your symptoms and any previous drug allergies you may have.

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