Medication Issues in Depression: Impact on Sleep and Self-Harm - Psychiatry

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Regarding issues related to antidepressant medications?


The diagnostic symptoms are F328 and F341.
The reason for the consultation is persistent self-harm, which has been ongoing for nearly a month.
The patient is currently on a regimen of 0.5 mg of Lurasidone and 10 mg of Desvenlafaxine daily.
Desvenlafaxine was increased from 5 mg to 10 mg during the last visit after being on 5 mg for the past three weeks.
Throughout the medication process, the patient has experienced daytime drowsiness daily.
Is this a side effect of the medication, or could the patient's emotional state also be contributing to the drowsiness?

Yijun, 10~19 year old female. Ask Date: 2017/06/19

Dr. Zhang Fangrong reply Psychiatry


Dear Sir/Madam,
Thank you for your inquiry.
Regarding the use of medication for depression, it typically takes about one to two weeks for the drug concentration in the brain to stabilize and take effect.
Therefore, you may want to continue monitoring the adjustment of your medication, such as Sertraline.
If you experience excessive daytime drowsiness, it is important to consider the impact of the medication, as other medications like Lamotrigine could also contribute to this.
Your physician likely prescribed these two medications considering your self-harm history.
As for coffee, please be mindful of your intake and physiological responses.
Consuming three cups a day is already at the recommended maximum amount.
Regarding alcohol, as long as you do not exhibit uncontrollable behaviors after drinking, including emotional instability, unsteady gait, or self-harm, and do not experience an increase in dosage, it should be acceptable.
We welcome your visit and wish you well-being.
Sincerely,
Dr.
Fang-Rong Chang
Department of Psychiatry

Reply Date: 2017/06/19

More Info


Understanding the interplay between medication, sleep disturbances, and self-harm in individuals diagnosed with depression can be quite complex. Your situation, which involves the use of medications such as 0.5 mg of Lurasidone (known as 乐稳) and 10 mg of Escitalopram (known as 得绪安), raises important questions about the effects of these medications on your sleep patterns and emotional state.

First, it's essential to recognize that both Lurasidone and Escitalopram are commonly prescribed for mood disorders, including depression and anxiety. Lurasidone is an atypical antipsychotic that can help stabilize mood and reduce symptoms of depression, while Escitalopram is a selective serotonin reuptake inhibitor (SSRI) that primarily targets serotonin levels in the brain to alleviate depressive symptoms. However, both medications can have side effects that may impact sleep.

One of the notable side effects of many antidepressants, including SSRIs like Escitalopram, is sedation or drowsiness, particularly when starting the medication or adjusting the dosage. This sedation can lead to feelings of excessive sleepiness during the day, which you have reported. It's crucial to communicate these side effects to your prescribing physician, as they may need to adjust your medication regimen or explore alternative treatments that might be less sedating.

Moreover, your emotional state plays a significant role in your sleep quality. Depression itself is often associated with sleep disturbances, including insomnia, hypersomnia (excessive sleepiness), and disrupted sleep patterns. The interplay between your mood and sleep is bidirectional; while depression can lead to sleep issues, poor sleep can exacerbate depressive symptoms. Therefore, it is not uncommon for individuals with depression to experience daytime sleepiness as a result of both the medication and the underlying mood disorder.

In your case, the increase in Escitalopram from 5 mg to 10 mg may also contribute to changes in your sleep patterns. When medications are adjusted, it can take some time for your body to adapt, and during this period, side effects such as drowsiness may become more pronounced. It's essential to monitor how you feel as you continue with this dosage and report any persistent issues to your healthcare provider.

Regarding self-harm, it's crucial to address this behavior seriously. Self-harm can be a coping mechanism for emotional distress, and while medication can help manage underlying symptoms, it is often beneficial to incorporate therapeutic interventions alongside pharmacological treatment. Cognitive-behavioral therapy (CBT) or dialectical behavior therapy (DBT) can provide you with tools to manage emotions and reduce self-harming behaviors effectively.

In summary, the drowsiness you are experiencing could be attributed to both the medications you are taking and the underlying depressive symptoms. It is vital to maintain open communication with your healthcare provider about your experiences with medication, sleep, and self-harm. They can help you navigate these challenges, potentially adjusting your treatment plan to better suit your needs. Additionally, consider seeking therapeutic support to address the emotional aspects of your condition, which can complement your medication regimen and improve your overall well-being.

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