Does Vitamin A Ester in Skincare Affect Fetal Development? - Obstetrics and Gynecology

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Does vitamin A ester have an effect on the fetus?


Hello Dr.
Tsao: I am currently almost six months pregnant.
I have been using a facial mask called "My Beauty Diary Purifying Pore Mask" since the early stages of my pregnancy.
I have always been careful to check for the presence of retinoids in my skincare products, but I recently discovered that the mask contains a compound called vitamin A ester, which I found online is also a form of retinoid.
I am very concerned about whether this could affect my baby's development and whether I should consider terminating my pregnancy.

Fang Fang, 30~39 year old female. Ask Date: 2017/11/23

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, it generally does not have an impact; just monitor it.
Wishing you good health.

Reply Date: 2017/11/23

More Info


When it comes to the use of skincare products containing Vitamin A esters during pregnancy, it is understandable to have concerns about their potential effects on fetal development. Vitamin A is crucial for many bodily functions, including vision, immune function, and skin health. However, it is also known that excessive intake of Vitamin A, particularly in the form of retinoids (which include retinol and its esters), can lead to teratogenic effects, meaning it can cause developmental issues in a fetus.

Vitamin A esters, such as retinyl palmitate and retinyl acetate, are often used in skincare products for their anti-aging and skin-renewing properties. While topical application of these compounds is generally considered to be safer than oral ingestion, there is still some debate among healthcare professionals regarding their use during pregnancy. The primary concern is that high levels of Vitamin A can cross the placenta and potentially affect fetal development.

Research indicates that the risk of teratogenic effects is primarily associated with high doses of Vitamin A taken orally, particularly in the first trimester. The FDA categorizes retinoids as Category X for oral use, meaning they are contraindicated in pregnancy due to the risk of birth defects. However, the risk associated with topical application of Vitamin A esters is not as clearly defined. Many dermatologists and obstetricians suggest that the risk from topical use is significantly lower than that from oral retinoids, especially when used in moderation.

In your case, since you have been using a mask containing Vitamin A ester, it is important to assess the concentration of this ingredient in the product. If the product is used as directed and is not excessively applied, the risk of harm to the fetus is likely minimal. However, it is always best to err on the side of caution during pregnancy. If you have concerns, it would be advisable to discontinue the use of any products containing Vitamin A esters and consult with your healthcare provider for personalized advice.

Regarding your worry about fetal development, it is crucial to remember that many women use skincare products during pregnancy without adverse effects. The best course of action is to maintain open communication with your healthcare provider, who can monitor your pregnancy and provide reassurance. If you have any specific concerns about fetal development or the use of certain products, do not hesitate to bring them up during your prenatal visits.

In summary, while Vitamin A esters in skincare products are generally considered to pose a lower risk than oral retinoids, it is prudent to avoid them during pregnancy if you have concerns. Always consult your healthcare provider for guidance tailored to your individual situation, and focus on maintaining a healthy lifestyle and prenatal care to support your baby's development.

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