Consumption of Baktar Tab 400 mg in individuals with G6PD deficiency can lead to hemolysis. The potential for long-term sequelae depends on the severity of the hemolytic episode. In most cases, if the hemolysis is mild and managed appropriately, there may be no lasting effects. However, severe hemolysis can lead to complications such as anemia or jaundice, which may require further medical evaluation and management. It is important to consult a healthcare professional for personalized advice and monitoring
Hello doctor, I recently visited a clinic for gastroenteritis and was prescribed Baktar Tab 400 mg, a sulfonamide antibiotic.
I informed them about my G6PD deficiency at the time.
After returning home, I found out that this medication is contraindicated for individuals with G6PD deficiency.
During my visit to the emergency room, my blood test showed slightly low red blood cell count at 4.38, elevated bilirubin at 1.67 mg/dL, and slightly low potassium at 3.3 due to diarrhea from gastroenteritis, while the rest of the results were normal.
I have been very worried lately.
Doctor, will hemolytic symptoms cause damage to my organs?
Yang Yuehua, 20~29 year old female. Ask Date: 2017/12/20
Dr. Wu Hongjie reply Internal Medicine
Hello: Individuals with favism (G6PD deficiency) may experience hemolysis and a decrease in hemoglobin levels when exposed to oxidizing agents.
The increase in bilirubin levels is indicative of hemolytic anemia, which can last approximately 8 to 14 days, depending on the oxidative effects of the medication.
If hemoglobin levels return to baseline after this period, it is unlikely to cause permanent organ damage.
However, if hemoglobin or red blood cell counts do not return to previous levels, it is advisable to seek assistance from a hematologist.
Wishing you health and safety.
Reply Date: 2017/12/20
More Info
Taking Baktar Tab 400 MG, which contains sulfonamides, can indeed pose risks for individuals with G6PD deficiency, commonly referred to as favism. This condition makes individuals susceptible to hemolytic anemia when exposed to certain medications, foods (like fava beans), or infections. The concern arises because sulfonamides can trigger oxidative stress in red blood cells, leading to their premature destruction, which is particularly dangerous for those with G6PD deficiency.
When a person with G6PD deficiency takes a medication like Baktar, they may experience hemolysis, which is the breakdown of red blood cells. Symptoms of hemolytic anemia can include fatigue, pallor, jaundice (yellowing of the skin and eyes), dark urine, and shortness of breath. In severe cases, hemolysis can lead to more serious complications, such as acute kidney injury due to the release of hemoglobin into the bloodstream, which can overwhelm the kidneys.
In your case, the blood test results you mentioned indicate a slightly low hemoglobin level (4.38) and elevated bilirubin (1.67 mg/dL), which can be signs of hemolysis. The low potassium level (3.3) could also be a result of gastrointestinal losses due to diarrhea, but it’s essential to monitor these levels closely, especially if hemolysis is suspected.
Regarding your concern about whether hemolytic symptoms can cause organ damage, the answer is yes, they can. Prolonged hemolysis can lead to complications such as:
1. Acute Kidney Injury: The kidneys can be damaged if they are overwhelmed by the breakdown products of red blood cells, particularly hemoglobin. This can lead to acute kidney injury, which may require medical intervention.
2. Heart Complications: Severe anemia can strain the heart, leading to increased heart rate and potentially heart failure in extreme cases.
3. Liver Damage: The liver processes bilirubin, and excessive hemolysis can lead to an overload of bilirubin, potentially causing liver dysfunction.
4. Infections: Individuals with hemolytic anemia may be more susceptible to infections due to the stress on the body and the potential for splenic dysfunction.
If you are experiencing symptoms of hemolysis or have concerns about your blood test results, it is crucial to follow up with your healthcare provider. They may recommend further testing, monitoring of your blood counts, and possibly treatment to manage any complications arising from hemolysis. In some cases, discontinuation of the offending medication and supportive care may be necessary.
In summary, while taking Baktar Tab 400 MG can lead to significant health risks for individuals with G6PD deficiency, prompt medical attention and monitoring can help mitigate these risks. Always communicate with your healthcare provider about any medications you are taking, especially if you have known conditions like G6PD deficiency.
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