HPV and Pap Smear Results: Key Questions Answered for Women - Obstetrics and Gynecology

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Inquiry about Human Papillomavirus (HPV)


Hello Doctor, I recently had my first Pap smear and human papillomavirus (HPV) test at the obstetrics and gynecology clinic.
The Pap smear result showed a grade of 2 indicating inflammation, and I tested positive for high-risk HPV type 56.
At the time of reviewing the report, I couldn't fully process the information, so I have a few questions for you:
1.
My doctor advised that I should have another Pap smear and HPV test in a year.
However, I've heard that Pap smears can have false negatives.
Is it possible that there are already precancerous changes that were not detected this time? Would waiting a year to retest be too long?
2.
I recently visited the clinic due to abnormal discharge, and I was diagnosed with bacterial vaginosis.
The doctor prescribed a suppository, and after about a week of treatment, I felt better.
However, during the Pap smear, the doctor noted that my cervix was still large and red, with a lot of discharge.
He mentioned that if the next Pap smear shows inflammation, I should receive proper treatment.
Yet, upon reviewing the report, the doctor said that inflammation does not require treatment.
Should I be concerned about this?
3.
The doctor mentioned that my cervix is large and red.
Could this be related to the HPV infection?
4.
In the unfortunate event that I develop cervical precancerous lesions in the future, will the HPV type 56 still be present after treatment? Is there a possibility that it could lead to cervical cancer again?
5.
Is it possible that the detected HPV is a virus that I already carry?
I apologize for the numerous questions, and I appreciate your time and patience in addressing them.
Thank you!

MM, 30~39 year old female. Ask Date: 2018/02/03

Dr. Zhang Kunmin reply Obstetrics and Gynecology


Hello, based on your description: 1.
Since there are no abnormal cells in this Pap smear, it is recommended to have a follow-up Pap smear in one year.
2.
After treating vaginal inflammation, the treating physician must determine, based on clinical judgment, whether the treatment is complete.
3.
The symptoms described are not related to HPV.
4.
The presence of the virus must be confirmed through testing; with proper treatment and follow-up with your physician, the risk of deterioration is very low.
5.
The source of the virus cannot be determined from this information.
Thank you! Wishing you peace and health, Dr.
Zhang.

Reply Date: 2018/02/03

More Info


Understanding HPV and Pap Smear Results: Key Questions Answered for Women
Human Papillomavirus (HPV) is a common sexually transmitted infection that can lead to various health issues, including cervical cancer. When you receive your Pap smear and HPV test results, it’s essential to understand what they mean and what steps to take next. Here’s a detailed response to your questions based on the information provided.

1. Pap Smear and False Negatives: It’s true that Pap smears can have false negatives, meaning that they might not detect existing abnormalities. However, if your doctor has recommended waiting a year for your next Pap smear and HPV test, it’s likely based on your current results and the standard guidelines for follow-up. Generally, if your Pap smear shows mild abnormalities (like a result of 2), and you have a high-risk HPV type, your doctor may suggest monitoring rather than immediate intervention. Nonetheless, if you have concerns about the possibility of undetected changes, you should discuss them with your doctor. If you experience any new symptoms or changes, it’s crucial to seek medical advice sooner rather than later.

2. Inflammation and Treatment: If your Pap smear indicated inflammation but your doctor suggested that treatment isn’t necessary, it may be because the inflammation is not severe or is likely due to a transient condition, such as a recent infection. However, if you continue to experience symptoms or if your cervical appearance (large and red) raises concerns, it’s worth discussing further treatment options. Persistent inflammation can sometimes be linked to HPV, but it can also result from other causes, such as infections or irritants.

3. Cervical Appearance and HPV: A large and red cervix can be indicative of various conditions, including infections, inflammation, or HPV infection. While HPV can cause changes in the cervical tissue, it’s essential to have a thorough evaluation to determine the exact cause of these changes. Your healthcare provider may recommend additional tests or monitoring to ensure that any underlying issues are addressed.

4. Risk of Cervical Cancer and HPV Persistence: If you were to develop cervical precancerous lesions (CIN), treatment typically involves removing the abnormal tissue, which can effectively eliminate the risk of progression to cervical cancer. However, the HPV type that caused the initial infection may remain in your system. While the immune system can clear many HPV infections over time, some high-risk types, like HPV 56, can persist and potentially lead to cancer if not monitored. Regular follow-ups and screenings are crucial to catch any changes early.

5. HPV Origin: It’s possible that the HPV detected in your test results is a new infection acquired through sexual contact. However, HPV can also remain dormant in the body for years, so it’s challenging to determine the exact origin of the virus. If you have had previous sexual partners, it’s possible that the virus was contracted earlier and only became detectable now.

In summary, it’s essential to maintain open communication with your healthcare provider regarding your HPV status and any symptoms you may experience. Regular screenings and follow-ups are vital in managing your health and reducing the risk of cervical cancer. If you have any concerns or notice changes in your health, don’t hesitate to seek medical advice sooner than the recommended follow-up period. Your health is a priority, and understanding your results is the first step in taking control of it.

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