Should You Get the 9-Valent HPV Vaccine After 4-Valent?

If you have already received the quadrivalent vaccine, do you need to receive the nonavalent vaccine?

Hello Doctor: I would like to ask if it is suitable for me to receive the new 9-valent HPV vaccine.
I received the quadrivalent HPV vaccine 10 years ago, but I was diagnosed with HPV type 58 two years ago.
However, my test results were negative last year.
I have had sexual intercourse and have been infected with type 58.

Nìmíng, 20~29 year old female. Ask Date: 2018/02/13

Dr. Huang Jianzhong reply Obstetrics and Gynecology

Ten years ago, I received the quadrivalent cervical cancer vaccine, but two years ago I was diagnosed with an HPV type 58 infection.
However, during a follow-up examination last year, the results were negative.
Is the new nine-valent vaccine suitable for me to receive now? Answer: It is very suitable.

Reply Date: 2018/02/13

More Info

The question of whether to receive the 9-valent HPV vaccine after having previously received the 4-valent HPV vaccine is an important one, especially considering your medical history of HPV infection. The 9-valent HPV vaccine protects against nine types of HPV, including the four types covered by the 4-valent vaccine (6, 11, 16, and 18) as well as five additional types (31, 33, 45, 52, and 58). Given that you were previously infected with HPV type 58, it is essential to understand the implications of this infection and the potential benefits of the 9-valent vaccine.

Firstly, it is important to note that while the 4-valent vaccine provides protection against certain high-risk HPV types, the 9-valent vaccine offers broader coverage. This means that even if you have had an HPV infection in the past, the 9-valent vaccine can still provide protection against other HPV types that you may not have been exposed to. The vaccine is designed to prevent future infections, so receiving it after having had a previous HPV infection can still be beneficial.

In your case, since you were infected with HPV type 58 but are currently HPV negative, getting the 9-valent vaccine could help protect you from other high-risk HPV types that may lead to cervical cancer or other HPV-related diseases. The vaccine is most effective when given before the onset of sexual activity; however, it can still provide benefits even after exposure to certain HPV types.

Regarding your previous infection with HPV type 58, it is important to understand that having had an HPV infection does not preclude you from receiving the vaccine. The immune response generated by the vaccine may not be as robust for the type you were previously infected with, but it can still enhance your immune protection against other types included in the vaccine.

Additionally, the Centers for Disease Control and Prevention (CDC) recommends that individuals who have previously received the 4-valent vaccine can still receive the 9-valent vaccine to increase their protection against additional HPV types. This is particularly relevant for individuals who are at risk of HPV-related diseases, including cervical cancer.

In summary, given your medical history and the benefits of the 9-valent HPV vaccine, it is advisable to consider receiving the vaccine. It can provide you with broader protection against HPV types that you may not have encountered and help reduce your risk of developing HPV-related health issues in the future. It is recommended that you discuss this with your healthcare provider, who can provide personalized advice based on your health history and current situation.

In conclusion, while you have a history of HPV infection, the 9-valent vaccine can still be a valuable addition to your preventive health measures. It is essential to stay proactive about your health and continue regular screenings as recommended by your healthcare provider. Vaccination, along with routine cervical cancer screenings, can significantly reduce your risk of developing HPV-related diseases.

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