Blood pressure, edema, uric acid?
Hello Dr.
Wu: My mother is 76 years old and has been taking Adalat 30 mg for many years.
Recently, she has experienced edema in her lower extremities.
We switched her to one Zanidip (Lercanidipine) 10 mg at bedtime and one Fluitran (Furosemide) 2 mg during the day.
Although the lower extremity edema has not returned, her systolic blood pressure has increased to 107-180 mmHg, while her diastolic pressure and pulse are normal.
Her uric acid level is 7.8.
What medication adjustments can be made to normalize her blood pressure and eliminate the edema?
Xiao Fen, 50~59 year old female. Ask Date: 2018/04/19
Dr. Xiao Yongxun reply Internal Medicine
Dear Miss Hsiao-Fen:
1.
Your mother is taking Adalat® (30mg; generic name Nifedipine), which is a calcium channel blocker.
Long-term use can lead to sodium and fluid retention, resulting in edema.
It is recommended to switch to Zanidip® (10mg; generic name Lercanidipine) and Fluitran® (2mg; generic name Trichlormethiazide).
The former is also a calcium channel blocker, and while it can still cause edema, it occurs less frequently than with Adalat®.
The latter is a diuretic that not only helps lower blood pressure but also alleviates edema, potentially counteracting the side effects of the former.
Therefore, this combination of medications seems very prudent.
2.
Regarding the increase in blood pressure after the medication change, please keep a detailed record of the blood pressure fluctuations and inform your attending physician for reference in adjusting the medication.
3.
In addition to medication management, maintaining good blood pressure also requires dietary, exercise, and lifestyle modifications.
This includes avoiding excessive salt, heavy flavors, oily foods, and overeating, as well as increasing physical activity, avoiding prolonged sitting, consuming more vegetables and fruits, drinking warm water, ensuring adequate sleep, and managing stress.
These changes can help improve blood pressure, uric acid levels, and edema.
4.
Your attending physician is very competent; if you have further questions, it is advisable to discuss them thoroughly with him.
(Note: My surname is Hsiao.)
Reply Date: 2018/04/19
More Info
Managing blood pressure and edema in elderly patients, particularly those with a history of hypertension and other comorbidities, requires a careful and individualized approach. In the case of your 76-year-old mother, who has been on long-term antihypertensive therapy with Adalat (nifedipine) and is now experiencing lower extremity edema, it is essential to consider both the pharmacological and non-pharmacological strategies to address her symptoms effectively.
Understanding the Situation
1. Current Medications: Your mother has been switched from Adalat to Zanidip (a calcium channel blocker) at night and Fluitran (a diuretic) during the day. While Zanidip can help manage blood pressure, it may not be as effective in controlling edema as diuretics. Fluitran, being a diuretic, is intended to help reduce fluid retention, but it may not be sufficient alone to manage her blood pressure effectively.
2. Blood Pressure Readings: The reported blood pressure readings of 107/180 mmHg indicate a significant elevation in systolic pressure, which is concerning. Isolated systolic hypertension is common in older adults and can lead to increased cardiovascular risk if not managed properly.
3. Edema Management: The presence of edema can be multifactorial, often related to heart function, kidney function, or the medications being used. In this case, the edema may have been exacerbated by the previous medication or underlying conditions such as heart failure or renal impairment.
Recommendations for Management
1. Medication Review: It is crucial to have a comprehensive review of all medications your mother is taking. The combination of Zanidip and Fluitran may need adjustment. It is advisable to consult with her healthcare provider to consider the following:
- Adjusting Diuretic Therapy: If Fluitran is not adequately controlling edema, a different diuretic or a higher dose may be necessary. Loop diuretics like furosemide (Lasix) can be more effective for significant fluid retention.
- Antihypertensive Regimen: The current antihypertensive regimen may need to be reassessed. Adding or switching to another class of antihypertensive medication, such as an ACE inhibitor or an ARB, could help manage blood pressure without exacerbating edema.
2. Monitoring and Follow-Up: Regular monitoring of blood pressure and renal function is essential. Blood pressure should be checked at different times of the day to understand its variability. Additionally, monitoring electrolytes, especially potassium levels, is crucial when using diuretics.
3. Lifestyle Modifications: Encourage your mother to adopt lifestyle changes that can help manage blood pressure and edema:
- Dietary Changes: A low-sodium diet can help reduce fluid retention. Increasing potassium intake through fruits and vegetables can also be beneficial, but this should be done under medical supervision, especially with diuretic use.
- Physical Activity: If her health allows, encourage light physical activity, which can improve circulation and help reduce edema.
- Elevation of Legs: Elevating her legs can help reduce swelling and improve venous return.
4. Addressing Underlying Conditions: Given her elevated uric acid level (7.8 mg/dL), it may be worth discussing with her physician the potential for gout or other related conditions that could be contributing to her overall health status. Managing uric acid levels may also help with her general well-being.
Conclusion
In conclusion, managing blood pressure and edema in your mother requires a multifaceted approach that includes medication adjustments, lifestyle changes, and regular monitoring. It is essential to work closely with her healthcare provider to tailor her treatment plan to her specific needs and ensure that both her blood pressure and edema are effectively managed. Regular follow-ups will be crucial in achieving optimal health outcomes for her.
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