HPV Infection: Why Your Test Results Changed - Dermatology

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Cauliflower (Condylomata Acuminata)


Hello doctor! Last October, I had an HPV DNA test, and the results were 59, 58, 42 ++++.
This year, the results changed to 18, 35, 58, 42 +++++.
Why is this happening? The doctor said I have been reinfected, but I haven't had sexual intercourse for almost six months.

Xiao Huang, 20~29 year old female. Ask Date: 2018/05/02

Dr. Wu Yuxin reply Dermatology


I cannot understand the values in your report.
A formal report is needed, and I recommend consulting an infectious disease specialist or a dermatologist for evaluation.

Reply Date: 2018/05/02

More Info


Understanding the dynamics of HPV (human papillomavirus) infection can be quite complex, especially when interpreting test results that seem to change over time. Your situation raises several important points that warrant a detailed explanation.

Firstly, it's essential to understand that HPV is a common sexually transmitted infection with many different strains, some of which are classified as high-risk due to their association with cervical cancer and other malignancies. The numbers you mentioned (e.g., 59, 58, 42, 18, 35) refer to specific HPV types. The presence of these types can vary over time due to several factors, including the body's immune response, sexual activity, and the nature of the virus itself.

1. Understanding Test Results: The change in your HPV DNA results from last year to this year indicates a shift in the types of HPV detected. The presence of different HPV types can occur due to new infections or the reactivation of dormant viruses. It's important to note that HPV can remain in a latent state in the body, meaning it may not always be detectable. Even if you haven't had sexual intercourse for six months, it's possible that the virus was already present in your system and became detectable due to changes in your immune status or other factors.

2. Re-infection vs. Reactivation: The statement from your doctor about a new infection could mean that you have been exposed to a different strain of HPV. However, it could also suggest that a previously undetectable strain has become active again. The immune system plays a crucial role in controlling HPV infections, and various factors, including stress, hormonal changes, and overall health, can influence this balance.

3. HPV Vaccination: If you have received the HPV vaccine, it is designed to protect against the most common high-risk HPV types, particularly types 16 and 18, which are most associated with cervical cancer. However, the vaccine does not treat existing infections. Therefore, if you were already infected with other HPV types not covered by the vaccine, those infections could still be present.

4. Implications for Health: It's crucial to maintain regular screenings, such as Pap smears and HPV tests, as recommended by your healthcare provider. While many HPV infections resolve on their own, some can persist and lead to precancerous changes in cervical cells. Monitoring your health through regular check-ups can help catch any potential issues early.

5. Communication with Your Healthcare Provider: Given the complexity of HPV and its implications for your health, it is vital to have open discussions with your healthcare provider. They can provide personalized advice based on your medical history, current health status, and test results. If you have concerns about the changes in your HPV status or the implications for your health, don't hesitate to ask for clarification or further testing.

In conclusion, while the changes in your HPV test results can be concerning, they are not uncommon. HPV is a dynamic virus, and its presence can fluctuate based on various factors. Regular monitoring and open communication with your healthcare provider are key to managing your health effectively. If you have further questions or concerns, consider seeking a consultation with a specialist in infectious diseases or a gynecologist who can provide more tailored insights based on your specific situation.

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