Escitalopram and Delayed Ejaculation: Concerns and Alternatives - Psychiatry

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Taking escitalopram 10 mg (an SSRI) can lead to delayed ejaculation?


Hello, doctor.
A few days ago, I visited a psychiatrist, and the doctor prescribed me medication for anxiety (which I inquired about in the previous two posts).
During this period, I have been experiencing difficulty with ejaculation.
Today marks the fourth day of taking the medication, and I found online that after discontinuing the medication, there may still be post-SSRI sexual dysfunction (PSSD) that can last for several years or even a lifetime, and the incidence rate is not small.
Can I stop taking the medication on my own? I am really hesitant to continue taking it.

Chen Dada, 20~29 year old female. Ask Date: 2018/05/05

Dr. Liang Sunyuan reply Psychiatry


Hello: Discontinuing this medication after a few days should not cause any discomfort; however, the original anxiety may still persist.
It is recommended to schedule an earlier follow-up appointment to discuss this with your outpatient physician.

Reply Date: 2018/05/05

More Info


Escitalopram, a selective serotonin reuptake inhibitor (SSRI), is commonly prescribed for anxiety and depression. While it can be effective in managing these conditions, it is also associated with various side effects, one of which is delayed ejaculation. This side effect can be particularly concerning for men, as it may affect sexual function and overall quality of life.

Delayed ejaculation is defined as a prolonged time to reach orgasm or an inability to ejaculate despite adequate sexual stimulation. This side effect occurs in a subset of patients taking SSRIs, including Escitalopram, and can be distressing. The mechanism behind this side effect is believed to be related to the increased serotonin levels in the brain, which can inhibit the ejaculatory reflex.

Your concerns about the potential for persistent sexual side effects, such as post-SSRI sexual dysfunction (PSSD), are valid. PSSD is a condition where individuals experience long-lasting sexual dysfunction even after discontinuing the medication. While the exact prevalence of PSSD is not well established, anecdotal reports suggest that it can occur in a minority of patients. However, it is essential to note that not everyone will experience these long-term effects, and many individuals find that their sexual function returns to baseline after stopping the medication.

Regarding your question about whether you can stop taking Escitalopram on your own, it is crucial to approach this decision with caution. Abruptly discontinuing an SSRI can lead to withdrawal symptoms and a potential exacerbation of the underlying anxiety or depression for which the medication was prescribed. It is generally recommended to taper off SSRIs gradually under the supervision of a healthcare provider to minimize withdrawal effects and monitor for the return of symptoms.

If you are experiencing significant distress due to delayed ejaculation, it is essential to discuss this openly with your prescribing physician. They may consider adjusting your medication regimen, such as switching to a different class of antidepressants that may have a lower risk of sexual side effects, like bupropion, or adding another medication to help mitigate the sexual side effects.
In addition to medication adjustments, there are also non-pharmacological approaches to managing delayed ejaculation. These may include sex therapy, cognitive-behavioral therapy, or pelvic floor exercises, which can help improve sexual function and reduce anxiety related to sexual performance.

In summary, while Escitalopram can be effective for anxiety and depression, it may cause delayed ejaculation and other sexual side effects. If you are concerned about these effects or the possibility of PSSD, it is vital to consult with your healthcare provider before making any changes to your medication regimen. They can help you weigh the benefits and risks, explore alternative treatments, and develop a plan that prioritizes both your mental health and sexual well-being.

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