Do Antibiotics Affect Birth Control Pills? Your Questions Answered - Pharmacology

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Emergency contraceptive pills and antibiotics?


Hello, I am currently taking the birth control pill Yaz.
After experiencing a toothache, I went for an extraction, and my doctor prescribed Keflex (cephalexin) and ketoprofen for me.
I took the antibiotic and pain reliever, and then an hour and a half later, I took my birth control pill.
I am wondering if this will affect the efficacy of the birth control pill.
Could you please help me confirm this? Thank you for your assistance.

Jiemi, 30~39 year old female. Ask Date: 2018/05/23

Dr. Chen Yuemei reply Pharmacology


Hello: After reviewing the literature, there are no reported interactions between the contraceptive pill you are taking and dental medications, so you can take them with confidence.

Reply Date: 2018/05/23

More Info


When it comes to the interaction between antibiotics and birth control pills, it's important to understand how these medications work and the potential implications for contraceptive efficacy. Generally, most antibiotics do not significantly affect the effectiveness of hormonal contraceptives like birth control pills. However, there are exceptions, and the specific antibiotic in question can play a crucial role.

The most commonly cited antibiotic that may interfere with birth control pills is rifampin, which is used to treat tuberculosis and some other infections. Rifampin can induce liver enzymes that metabolize hormones in birth control pills, potentially reducing their effectiveness. However, the antibiotics Keflex (cephalexin) and Ketoprofen, which you mentioned taking, are not known to have this effect. Keflex is a cephalosporin antibiotic, and studies have shown that it does not significantly impact the effectiveness of hormonal contraceptives.

In your case, taking Keflex and Ketoprofen approximately one and a half hours before your birth control pill should not compromise the effectiveness of your contraceptive method. The timing of when you took the antibiotics relative to the birth control pill is also unlikely to be an issue, as the primary concern with antibiotics and birth control interactions typically arises when antibiotics are taken over a longer duration or when they are known to affect liver enzymes.

It's also worth noting that while antibiotics like Keflex do not interfere with birth control pills, they can sometimes cause gastrointestinal side effects, such as diarrhea or vomiting. If these side effects are severe enough, they could potentially affect the absorption of the birth control pill, leading to decreased effectiveness. If you experience significant gastrointestinal symptoms, it may be wise to use a backup contraceptive method, such as condoms, until you are certain that your birth control pill is being absorbed effectively.

In summary, based on the information provided, taking Keflex and Ketoprofen should not affect the efficacy of your birth control pills. However, if you have any lingering concerns or experience any unusual symptoms, it is always a good idea to consult with your healthcare provider for personalized advice. They can provide you with the most accurate information based on your specific health situation and the medications you are taking.

In addition to this, it's essential to maintain open communication with your healthcare provider about all medications you are taking, including over-the-counter drugs and supplements, as well as any changes in your health status. This will help ensure that you receive the best possible care and that any potential interactions are managed appropriately.

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