Do Antibiotics Like Keflex Affect Birth Control Pills? - Obstetrics and Gynecology

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Antibiotics affect birth control pills?


I would like to ask if Keflex 500 mg will affect the effectiveness of oral contraceptives, or if there is a specific time interval that should be maintained when taking the contraceptive pill?

Sjseid, 10~19 year old female. Ask Date: 2019/05/21

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, I apologize for the delay in responding to your message due to some matters.
Antibiotics do not affect birth control pills.
Wishing you good health.

Reply Date: 2019/05/21

More Info


When it comes to the interaction between antibiotics like Keflex (cephalexin) and birth control pills, the concern primarily revolves around whether antibiotics can diminish the effectiveness of hormonal contraceptives. Keflex is a type of cephalosporin antibiotic that is commonly used to treat bacterial infections.
The general consensus in the medical community is that most antibiotics do not significantly affect the efficacy of birth control pills. The primary antibiotic that has been shown to potentially interfere with hormonal contraceptives is rifampin, which is used to treat tuberculosis and certain other infections. Rifampin can induce liver enzymes that metabolize hormones, thereby reducing the effectiveness of birth control pills. However, Keflex does not have this effect.

According to the Centers for Disease Control and Prevention (CDC) and other health organizations, there is no substantial evidence that cephalosporins like Keflex interfere with the effectiveness of birth control pills. Therefore, if you are taking Keflex while on birth control pills, you should not need to worry about a significant decrease in contraceptive effectiveness.
However, it is always prudent to take certain precautions. Here are some recommendations:
1. Consistency is Key: Continue taking your birth control pills as prescribed, without missing doses. Consistent use is crucial for maintaining their effectiveness.

2. Consult Your Healthcare Provider: If you have concerns about drug interactions or if you are prescribed any new medications, it is always best to discuss these with your healthcare provider. They can provide personalized advice based on your medical history and current medications.

3. Use Backup Contraception: If you are concerned about potential interactions, consider using a backup method of contraception, such as condoms, while taking antibiotics. This can provide an extra layer of protection.

4. Monitor for Side Effects: If you experience any unusual side effects or changes in your menstrual cycle while taking antibiotics, consult your healthcare provider. This can help rule out any issues related to medication interactions or other health concerns.

5. Stay Informed: Keep yourself informed about the medications you are taking. Understanding how they work and their potential interactions can empower you to make informed decisions about your health.

In summary, Keflex is not known to affect the effectiveness of birth control pills significantly. However, maintaining consistent use of your contraceptive method and consulting with your healthcare provider for any concerns is always a wise approach. If you have any further questions or specific concerns about your medications, don't hesitate to reach out to your healthcare provider for tailored advice.

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