Adjusting Oral A Acid Dosage for Acne Management: Expert Advice - Dermatology

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Oral isotretinoin issues?


Hello Doctor: Previously, I took one 20 mg pill daily for about a year and stopped because my skin condition improved.
However, recently I have started to notice a few pimples returning on my back, chest, and face, and my face has become quite oily.
I would like to ask if I can switch to taking one 20 mg pill every two days, or should I continue with one 20 mg pill daily? If I take one 20 mg pill every two days, should I take one 10 mg pill daily instead, or continue with one 20 mg pill? Thank you for your response!

Sun Xiansheng, 20~29 year old female. Ask Date: 2018/06/03

Dr. Wu Yuxin reply Dermatology


You should consult your attending physician about this issue, as they are most familiar with your condition and can help you choose the appropriate medication.

Reply Date: 2018/06/03

More Info


When it comes to adjusting the dosage of oral isotretinoin (commonly known as A acid) for acne management, it's essential to approach this with caution and under the guidance of a healthcare professional. Isotretinoin is a powerful medication that can significantly improve acne but also comes with potential side effects and requires careful monitoring.

Given your history of taking isotretinoin at a dosage of 20 mg daily for about a year, and now experiencing a resurgence of acne on your back, chest, and face, it’s understandable that you’re considering a dosage adjustment. However, the decision to change your dosage should ideally be made in consultation with your dermatologist or healthcare provider, who can assess your current skin condition and overall health.


Dosage Considerations
1. Current Dosage: You mentioned that you were taking 20 mg daily. This is a common starting dose for many patients, and it can be effective for managing moderate to severe acne. If you have been off the medication for a while and are now experiencing breakouts, it might be tempting to reduce the frequency of your dosage to every other day (20 mg every two days). However, this could lead to suboptimal results since isotretinoin works best when taken consistently.

2. Alternative Dosing: If you are considering taking 10 mg daily instead (which would be equivalent to 20 mg every two days), this is a viable option. Lowering the dose can help mitigate side effects while still providing some therapeutic benefit. However, the effectiveness of this lower dose may vary from person to person.
3. Consultation with Your Doctor: It is crucial to discuss your concerns and any potential changes in dosage with your dermatologist. They can provide personalized advice based on your skin type, the severity of your acne, and your previous response to the medication. They may also want to monitor your liver function and lipid levels, as isotretinoin can affect these parameters.


Managing Side Effects
While isotretinoin can be very effective, it can also lead to side effects such as dryness, sensitivity, and in some cases, more severe reactions. If you experience any unusual symptoms, such as severe dryness, mood changes, or any other concerning side effects, it’s essential to report these to your healthcare provider immediately.


Additional Treatments
In addition to isotretinoin, your dermatologist may suggest adjunct therapies to help manage your acne. These can include topical treatments, antibiotics, or hormonal therapies, depending on the underlying causes of your acne.

Conclusion
In summary, while adjusting your isotretinoin dosage may be necessary due to your recent acne flare-ups, it is vital to do so under the supervision of your healthcare provider. They can help you determine the most appropriate dosage and monitor your progress to ensure the best possible outcome. Remember, managing acne is often a multifaceted approach, and your dermatologist can guide you through the best options tailored to your specific needs.

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