Long-Term Effects of Lutein and Fish Oil on Liver and Kidney Health - Pharmacology

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Hello, I have been undergoing traditional Chinese medicine treatment for floaters for a month and am also taking lutein and fish oil.
I would like to know if long-term use of these supplements could put a strain on my liver and kidneys.
I am concerned about the potential burden since traditional Chinese medicine treatment requires some time.
Additionally, is there an optimal time to take lutein and fish oil? Thank you!

Niming, 20~29 year old female. Ask Date: 2018/06/09

Dr. Hou Fangmin reply Pharmacology


Hello: Lutein supplementation typically requires about 6 months.
Lutein is a fat-soluble nutrient, and it is recommended to take it after breakfast for better absorption.
Taking it in the evening may increase the burden on the liver.
Please do not exceed 6 mg per day.
It is also advisable to consume more natural sources such as sweet potato leaves, spinach, kiwi, and bananas.
You can increase your intake of fish oil by consuming more fish.
Avoid prolonged use of electronic devices, and if you take it for an extended period, consider getting your liver and kidney function checked at a hospital.
Generally, routine tests are fine, but it is important to pay attention to your diet and eye care.
Finally, I wish you peace and joy.

Reply Date: 2018/06/09

More Info


When considering the long-term effects of lutein and fish oil on liver and kidney health, it's essential to understand the individual roles these supplements play in the body, as well as their potential impacts on organ function.

Lutein is a carotenoid found in green leafy vegetables and is known for its antioxidant properties. It is particularly beneficial for eye health, as it helps filter harmful blue light and protects the retina from oxidative stress. Research suggests that lutein may also have a positive effect on cognitive function and cardiovascular health. Importantly, lutein is generally considered safe for long-term use, and there is no substantial evidence indicating that it poses a risk to liver or kidney health when taken at recommended dosages.

Fish oil, on the other hand, is rich in omega-3 fatty acids, particularly EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid). These fatty acids are well-known for their anti-inflammatory properties and have been shown to support cardiovascular health, reduce triglyceride levels, and potentially improve joint health. However, excessive intake of fish oil can lead to adverse effects, such as increased bleeding risk due to its blood-thinning properties. For individuals with pre-existing liver or kidney conditions, it is crucial to monitor the dosage and consult with a healthcare provider to ensure safety.

Regarding your concern about the potential burden on the liver and kidneys from long-term use of these supplements, both lutein and fish oil are generally well-tolerated. However, if you have underlying health conditions or are taking other medications, it is advisable to have regular check-ups and blood tests to monitor liver and kidney function. This is particularly important if you are consuming high doses of fish oil, as it can affect coagulation and may require adjustments based on your health status.

As for the optimal timing for taking lutein and fish oil, there are some recommendations to consider. Fish oil is best absorbed when taken with meals, particularly those containing fat, as this enhances the bioavailability of omega-3 fatty acids. Therefore, taking fish oil with a meal that includes healthy fats (like avocados, nuts, or olive oil) can be beneficial. Lutein can also be taken with meals, especially those rich in fats, to improve its absorption, as it is a fat-soluble nutrient.

In summary, both lutein and fish oil can be part of a healthy regimen, especially for eye health and cardiovascular support, respectively. They are generally safe for long-term use, but it is essential to monitor your health, especially if you have existing conditions or are undergoing treatment. Always consult with your healthcare provider before making any significant changes to your supplement routine, particularly if you are concerned about potential impacts on your liver and kidney health. Regular monitoring and a balanced diet can help mitigate any risks associated with long-term supplementation.

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