Withdrawal Symptoms from Sleep Medications: A Guide - Psychiatry

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The issue of withdrawal from sleeping pills?


Hello doctor, I have been taking Lurasidone 10 mg and Escitalopram 2 mg for over four years.
My sleep issues have improved during this time.
There have been 2 to 3 instances where I felt better and discussed tapering off the medication with my doctor (due to minor issues like memory decline); however, each time I reduce the dose of Escitalopram, I experience uncomfortable symptoms, not insomnia, but rather daytime restlessness, anxiety, difficulties in expression, and an unusual feeling of fatigue during the day.
I would like to know if these withdrawal symptoms from Escitalopram are normal and how long they might last.
Should I persist with tapering off the medication slowly, or should I resume taking it? Do you have any recommendations? Thank you, doctor!

Wei, 20~29 year old female. Ask Date: 2018/07/25

Dr. Huang Xiaoxian reply Psychiatry


Hello, the sleeping medication you are taking is not considered a strong sedative, and the dosage is within a reasonable range.
By gradually tapering the dosage and incorporating other supportive therapies, there is a possibility to gradually reduce its use.
It is advisable to discuss the reduction method further with your physician, and you are also welcome to visit our clinic for more information.

Reply Date: 2018/07/25

More Info


When it comes to managing sleep issues, particularly when using medications like Lexapro (escitalopram) and sleep aids such as Zolpidem (often referred to by its brand name, Ambien), it is crucial to understand the potential withdrawal symptoms and the importance of a careful tapering process. Lexapro is an antidepressant that belongs to the selective serotonin reuptake inhibitor (SSRI) class, commonly prescribed for anxiety and depression. Zolpidem is a sedative-hypnotic used for short-term treatment of insomnia.

Withdrawal symptoms from sleep medications can vary significantly from person to person. In your case, after reducing the dosage of Zolpidem, you experienced feelings of agitation, anxiety, and cognitive difficulties, which are not uncommon. These symptoms can occur as your body adjusts to the absence of the medication, especially if it has been used for an extended period. The duration and intensity of withdrawal symptoms can depend on several factors, including the dosage, duration of use, and individual physiology.

It is essential to recognize that both Lexapro and Zolpidem can lead to dependence, and stopping them suddenly can result in withdrawal symptoms. For Zolpidem, common withdrawal symptoms may include rebound insomnia, anxiety, irritability, and cognitive impairments. For Lexapro, discontinuation symptoms can include mood swings, anxiety, dizziness, and flu-like symptoms. These symptoms can last from a few days to several weeks, depending on how long you have been taking the medication and how quickly you taper off.

Given your experience, it is advisable to consult with your healthcare provider before making any changes to your medication regimen. A gradual tapering schedule is often recommended to minimize withdrawal symptoms. Your doctor can help you create a personalized tapering plan that considers your specific situation, including your history of medication use and any side effects you may have experienced.

In addition to medication management, consider incorporating non-pharmacological strategies to improve your sleep and overall well-being. Cognitive-behavioral therapy for insomnia (CBT-I) is an effective treatment that focuses on changing sleep habits and misconceptions about sleep. Mindfulness practices, relaxation techniques, and maintaining a consistent sleep schedule can also be beneficial.

Furthermore, lifestyle changes such as regular physical activity, a balanced diet, and good sleep hygiene can significantly impact your sleep quality. Avoiding caffeine and heavy meals close to bedtime, creating a comfortable sleep environment, and establishing a calming pre-sleep routine can help enhance your sleep without relying solely on medication.

In summary, while it is normal to experience withdrawal symptoms when tapering off medications like Zolpidem and Lexapro, it is crucial to do so under the guidance of a healthcare professional. They can provide support and strategies to manage any discomfort you may experience during this process. Additionally, exploring non-drug interventions can contribute to long-term improvements in your sleep and mental health. Always prioritize open communication with your healthcare provider to ensure the best outcomes for your treatment plan.

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