Exploring Treatment Options for Anal Warts: A Patient's Dilemma - Surgery

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Consultation for Treatment Options for Anal Condylomata Acuminata?


Hello, Doctor: I have been diagnosed with anal intraepithelial neoplasia (AIN) caused by condylomata acuminata.
I have consulted two physicians at a major hospital, and both recommended electrosurgery as the treatment.
After doing some research, I found that most topical treatments are aimed at external lesions rather than internal ones.
However, I spent a considerable amount of time searching and came across a medical article from the Journal of the European Academy of Dermatology and Venereology, which states that anal condylomata can be treated with a topical application of "0.5% podophyllotoxin solution" via anoscopy.
The source of the article is: http://www.uho.com.tw/Print.asp?aid=2615.

I attempted to show this treatment method to the colorectal surgeons, but they firmly stated that topical treatments are generally ineffective and were unwilling to consider this approach.
Subsequently, I found a colorectal surgeon nearby who was willing to try this treatment, and he applied the medication once a week, although not as frequently as suggested in the literature.
I still feel conflicted and struggle with the decision, fearing that my choice might resemble those cancer patients who believe in alternative therapies, ultimately worsening their condition and wasting money.
I understand and am prepared for the possibility that if the topical treatment does not work, I may need surgery.
However, my fear of pain and the recovery period has led me to consider a more gradual approach.
The physician's statement that "it is basically ineffective" has left a strong impression on me, contributing to my dilemma.
I would like to ask: 1.
As a fellow physician, do you have any insights or opinions regarding this conflict and the differing viewpoints? Are there any other medical studies or data that could assist me in making a decision? 2.
I understand that electrosurgery is a more definitive approach to remove the lesions quickly, and while both methods lack guaranteed effectiveness in preventing recurrence, I wonder if the treatment mentioned in the literature is truly as ineffective as the physicians I consulted suggested.
Or is it possible that most physicians prefer a more aggressive and immediate method, rather than genuinely believing that topical treatments cannot be effective? Thank you.

QQ, 20~29 year old female. Ask Date: 2018/08/17

Dr. Ke Fangxu reply Surgery


Answer: Since I cannot see your lesion, I cannot assess the severity.
If most doctors do not recommend topical medication, it likely indicates a serious condition; otherwise, no physician enjoys performing such surgeries as they are both complicated and prone to recurrence.
The National Health Insurance only reimburses a few hundred dollars for this, so the doctors willing to perform the surgery are quite conscientious.
Otherwise, they could simply prescribe a topical ointment and send you on your way.
Generally, topical medications are only recommended for early, mild cases.
If the lesion has reached a certain size, there is no miracle drug that will resolve it with just one application.
Moreover, many medications available abroad are not accessible domestically, and self-applying unknown substances without a doctor's evaluation is not advisable, as it may lead to adverse effects.
I recommend facing the reality of your situation and actively pursuing treatment.

Reply Date: 2018/08/17

More Info


When it comes to the treatment of anal warts, particularly those caused by the human papillomavirus (HPV), patients often find themselves navigating a complex landscape of options and opinions from healthcare professionals. Your situation, involving the diagnosis of anal warts (condylomata acuminata), is not uncommon, and it raises important questions about treatment efficacy, patient preferences, and the balance between invasive procedures and topical therapies.

1. Understanding Treatment Options: The primary treatments for anal warts include surgical options such as electrosurgery, cryotherapy, and laser therapy, as well as topical treatments like imiquimod, podophyllin, and, as you mentioned, the application of 0.5% cantharidin solution. While surgical methods are often favored for their immediate results, they can come with risks such as pain, scarring, and longer recovery times. On the other hand, topical treatments may be less invasive and allow for a more gradual approach, but they often require consistent application and may take longer to show results.

2. Efficacy of Topical Treatments: The skepticism from some healthcare providers regarding the efficacy of topical treatments for internal anal warts is rooted in clinical experience and the nature of HPV. While topical agents can be effective for external warts, their effectiveness for internal lesions can vary. The study you referenced from the Journal of the European Academy of Dermatology and Venereology suggests that cantharidin can be used for internal warts, but this may not be a universally accepted practice. The reluctance of some physicians to endorse this method could stem from a lack of robust clinical trials specifically supporting its use for internal warts, as well as concerns about the potential for irritation or adverse effects.

3. Patient-Centric Decision Making: Your concerns about the potential ineffectiveness of topical treatments and the fear of invasive procedures are valid. It’s essential to weigh the benefits and risks of each treatment option. If you are inclined to try the topical treatment, it may be worth discussing a structured approach with the physician who is willing to administer it. This could involve a clear treatment plan with regular follow-ups to assess progress. If the topical treatment does not yield satisfactory results, you can then consider more invasive options with a clearer understanding of your condition.

4. Seeking a Second Opinion: Given the conflicting opinions you’ve encountered, seeking a second opinion from a specialist in dermatology or a colorectal surgeon with experience in treating anal warts could provide additional insights. They may have access to the latest research and treatment protocols that could inform your decision.

5. Research and Evidence: It’s important to consider that while anecdotal evidence and personal experiences shared online can be helpful, they do not replace clinical evidence. You might want to look for systematic reviews or meta-analyses that evaluate the effectiveness of various treatments for anal warts, particularly those that focus on internal lesions. This can provide a more comprehensive understanding of the potential outcomes associated with different treatment modalities.

In conclusion, your dilemma reflects a broader challenge faced by many patients dealing with HPV-related conditions. The decision-making process should involve a thorough discussion with your healthcare provider about the risks and benefits of each treatment option, taking into account your personal preferences and concerns. Ultimately, the goal is to find a treatment plan that aligns with your values while effectively addressing the condition.

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