Is Two Injections of Third-Generation Cephalosporins Enough for Gonorrhea Treatment? - Urology

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Medications for Gonorrhea


I tested positive for gonorrhea, and the doctor administered two intramuscular injections of a third-generation cephalosporin on the first and eighth days.
I did not take any oral medication.
Does this mean the treatment is complete? Thank you, doctor.

Maike, 50~59 year old female. Ask Date: 2018/09/06

Dr. Chen Jiansheng reply Urology


If you are concerned, you can have another urine test done.

Reply Date: 2018/09/06

More Info


When it comes to treating gonorrhea, the current guidelines from health authorities, including the Centers for Disease Control and Prevention (CDC), recommend a specific regimen to effectively eradicate the infection. Gonorrhea is caused by the bacterium Neisseria gonorrhoeae, and it can lead to serious health complications if not treated properly.
The standard treatment for uncomplicated gonorrhea typically involves a dual therapy approach. This usually consists of a single dose of intramuscular ceftriaxone (a third-generation cephalosporin) combined with oral azithromycin. The rationale behind this dual therapy is to ensure that the treatment is effective against potential antibiotic-resistant strains of gonorrhea, which have been increasingly reported in recent years.

In your case, you mentioned receiving two injections of a third-generation cephalosporin on the first and eighth days. While ceftriaxone is indeed effective against gonorrhea, the treatment regimen you received does not align with the recommended guidelines. The CDC's current recommendations emphasize the importance of administering a single dose of ceftriaxone along with azithromycin to achieve optimal treatment outcomes.

It's also important to note that the timing of the injections and the absence of oral antibiotics may not provide sufficient coverage against the infection. The two injections alone may not be enough to ensure that the gonorrhea is fully treated, especially considering the potential for antibiotic resistance.

After receiving treatment for gonorrhea, it is crucial to follow up with your healthcare provider. They may recommend a test of cure, especially if symptoms persist or if you are at risk for reinfection. This follow-up is essential to confirm that the infection has been successfully eradicated.

In summary, while ceftriaxone is an effective treatment for gonorrhea, the regimen you received may not be sufficient according to current guidelines. It is advisable to consult your healthcare provider for further evaluation and to discuss the possibility of additional treatment, including the use of azithromycin, to ensure complete resolution of the infection. Always remember that open communication with your healthcare provider is key to managing your health effectively.

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