HPV, Warts, and Pseudo-Warts: A Comprehensive Guide - Obstetrics and Gynecology

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HPV testing / genital warts / pseudocondylomata


Hello doctor, I have had bumps on my labia that resemble keratosis for nearly a year without worsening or spreading.
After a year, I felt it was necessary to get checked.
The first clinic tested for HPV and found infections with types 18, 52, and 62.
A biopsy of the bumps indicated they were warts, but two other clinics performed internal examinations and suggested they resembled pseudocondylomas, with no lesions found in the vagina.
Later, I purchased a wart removal gel and applied it to the larger bumps, which have increased in size but also have fallen off.

Q1: Can pseudocondylomas react to wart removal gel?
Q2: Is it possible for a biopsy to have discrepancies?
Q3: If they are warts, is it possible to have lesions that have not worsened or improved over nearly a year?

Ms. L, 20~29 year old female. Ask Date: 2018/10/26

Dr. Huang Jianzhong reply Obstetrics and Gynecology


The labia majora have a texture similar to keratosis and have not been smooth for nearly a year without worsening or spreading.
After a year, I felt something was off and decided to get checked.
The first clinic tested for HPV and found infections with types 18, 52, and 62.
Additionally, a biopsy of the bumps indicated they were condylomas, but two other clinics, after performing a pelvic examination, suggested they resembled pseudocondylomas, and there were no lesions found in the vagina.
Later, I purchased an over-the-counter wart remover and applied it to the larger bumps, which have since increased in size and some have fallen off.

Q1: Can pseudocondylomas react to wart remover?
A: Yes, they can react.
Q2: Is it possible for a biopsy to have discrepancies?
A: In theory, there should not be discrepancies in a biopsy.
Q3: If it is condyloma, is it possible to have lesions that have not worsened or improved for nearly a year?
A: Yes, that is possible.

Reply Date: 2018/10/26

More Info


Understanding HPV, Warts, and Pseudo-Warts: A Comprehensive Guide
Human Papillomavirus (HPV) is a common sexually transmitted infection that can lead to various health issues, including genital warts and certain types of cancer. The virus has over 100 different strains, some of which are classified as high-risk due to their association with cancer, while others are considered low-risk and primarily cause warts. In your case, it seems you have encountered a complex situation involving HPV and potential warts, which warrants a thorough understanding of the virus and its implications.


Q1: Can pseudo-warts react to wart treatments like wart removal gel?
Pseudo-warts, or pseudo-condylomas, are growths that may resemble genital warts but are not caused by HPV. They can arise from various factors, including irritation or other non-viral causes. When you apply a wart removal gel, which typically contains salicylic acid or other agents designed to treat viral warts, you may observe a reaction. This reaction could manifest as irritation, redness, or even peeling of the skin. However, since pseudo-warts are not caused by HPV, the treatment may not effectively eliminate them, and any changes you observe could be due to the skin's response to the treatment rather than the removal of a viral infection.


Q2: Is it possible for a biopsy to yield inaccurate results?
Biopsies are generally reliable diagnostic tools, but there is always a possibility of error. Factors that can contribute to inaccuracies include the sampling technique, the area from which the sample is taken, and the pathologist's interpretation. If the biopsy was taken from an area that does not represent the entire lesion or if the lesion has atypical features, it may lead to a misdiagnosis. In your case, if the biopsy indicated the presence of warts but subsequent examinations suggested otherwise, it may be worth discussing with your healthcare provider the possibility of a second opinion or further testing to clarify the diagnosis.


Q3: If it is indeed genital warts, can they remain unchanged for an extended period?
Genital warts caused by HPV can indeed remain stable for long periods without significant changes. Many individuals with HPV may not experience any symptoms, and the immune system can sometimes keep the virus in a dormant state. In your situation, if the warts have not changed in size or appearance over the course of a year, it is possible that your immune system is managing the virus effectively. However, it is essential to monitor any changes and maintain regular check-ups with your healthcare provider, as the behavior of warts can vary significantly among individuals.


Additional Considerations
1. HPV Vaccination: If you have not yet been vaccinated against HPV, consider discussing the HPV vaccine with your healthcare provider. The vaccine can protect against the most common high-risk strains of HPV and can be beneficial even if you have already been exposed to some strains.

2. Regular Screening: Regular gynecological examinations and Pap smears are crucial for early detection of any changes in cervical health, especially if you have a history of HPV infection.

3. Immune Health: Maintaining a healthy immune system can help your body manage HPV more effectively. This includes a balanced diet, regular exercise, adequate sleep, and stress management.

4. Communication with Partners: If you are sexually active, it is essential to communicate with your partners about HPV and safe sex practices to reduce the risk of transmission.

In conclusion, understanding HPV and its implications is vital for managing your health. If you have concerns about your diagnosis or treatment, do not hesitate to seek a second opinion or consult a specialist in infectious diseases or dermatology for further evaluation.

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