Thyroid Issues and Autoimmune Diseases Linked to Uterine Drug Systems - Breast and Thyroid

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Thyroid issues, intrauterine drug delivery system autoimmune diseases?


Due to endometriosis and severe adenomyosis, I have had the Mirena IUD for a total of 6 years.
During these years, I have also been diagnosed with Sjögren's syndrome, thyroiditis, and my lipid profile shows total cholesterol at 209, LDL at 134, HDL at 55, and blood glucose at 101 with an A1C of 5.7.
I have gained 8 kg, and all of these changes occurred during the time I had the Mirena.
I have heard that many users abroad have had their thyroid function return to normal after removing the IUD.
Could my condition be caused by the Mirena? Should I consider having it removed? I'm feeling uncertain about what to do.

Yuping, 40~49 year old female. Ask Date: 2018/11/11

Dr. Yuan Tianmin reply Breast and Thyroid


This issue falls under the specialty of obstetrics and gynecology.

Reply Date: 2018/11/11

More Info


The concerns you have regarding the potential link between your uterine drug system (Mirena IUD) and the onset of autoimmune diseases, including thyroid issues, are valid and warrant careful consideration. The Mirena IUD releases levonorgestrel, a synthetic progestin, which is primarily used for contraception and to manage heavy menstrual bleeding. While it is generally considered safe for most users, there are reports and studies that suggest a possible association between hormonal contraceptives and autoimmune conditions.

Autoimmune diseases, such as Hashimoto's thyroiditis (which is a form of thyroiditis that can lead to hypothyroidism), are complex and multifactorial. They can be influenced by genetic predisposition, environmental factors, and hormonal changes. The onset of these conditions during the time you have had the Mirena IUD could be coincidental, but it is also possible that hormonal changes induced by the IUD may have played a role in exacerbating or triggering these conditions.

Your reported symptoms, including weight gain and changes in lipid profiles, can also be influenced by hormonal fluctuations. Hormonal contraceptives can affect metabolism, appetite, and fat distribution, which might explain the weight gain you have experienced. Additionally, thyroid dysfunction can lead to alterations in lipid metabolism, resulting in elevated cholesterol levels.

Regarding the experiences of other users who reported normalization of thyroid function after removal of the IUD, it is important to note that individual responses to hormonal contraceptives can vary widely. Some women may experience relief from symptoms after removal, while others may not notice any significant changes. It is essential to approach this situation with a comprehensive evaluation by a healthcare provider who can assess your overall health, including thyroid function tests and autoimmune markers.

If you are considering the removal of the Mirena IUD, it is crucial to discuss this with your healthcare provider. They can help you weigh the potential benefits and risks, considering your current health status and any underlying conditions. It may also be beneficial to consult an endocrinologist, particularly one who specializes in thyroid disorders, to gain further insight into your thyroid health and how it may relate to your use of the IUD.

In summary, while there may be a potential link between the Mirena IUD and the onset of autoimmune diseases, it is essential to conduct a thorough evaluation before making any decisions about removal. Your healthcare provider can guide you through this process, ensuring that you receive appropriate care tailored to your individual needs. Remember, the management of autoimmune diseases often requires a multidisciplinary approach, and addressing lifestyle factors, diet, and stress management can also play a significant role in your overall health and well-being.

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