Urine Test Results: Uribilinogen Levels and Health Concerns - Internal Medicine

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In the recent health check report, a urine urobilinogen level of "1+" indicates a mild presence of urobilinogen in the urine. Urobilinogen is a byproduct of bilirubin reduction, and its levels can provide insights into liver function and hemolysis. A "1+" result is generally considered within the normal range, but it may warrant further evaluation if accompanied by other abnormal findings or symptoms. It is advisable to consult with a healthcare professional for a comprehensive interpretation in the context of your overall health?


Dear Dr.
Lin,
I have a few questions regarding my recent health check-up report:
1.
The report shows that the urine urobilinogen level is "1+" and the urine bilirubin is negative.
What does this mean? I underwent a cholecystectomy at the end of April this year, and I am wondering if there is any correlation.
My previous health check-up reports were normal.
2.
I have a history of hypertension and am currently taking antihypertensive medication, which is being well managed.
During my follow-up visit, the clinic doctor mentioned that my condition is under good control.
However, in September, my glomerular filtration rate (GFR) was measured at 96, and urine protein was negative.
In October, during my health check-up, my GFR dropped to 77.29, and urine protein was "+/-." I am confused about which result is accurate, as the difference is significant.
3.
My fasting blood glucose level is 100, and my hemoglobin A1c is 5.7.
Is treatment necessary for this?
Thank you very much for taking the time to respond, Dr.
Lin.
I greatly appreciate it!

Kunhuo, 40~49 year old female. Ask Date: 2018/11/22

Dr. Lin Wuxuan reply Internal Medicine


Hello: The normal value for urobilinogen is less than 1.0 E.U/dL, and your test result is 1.0, which is actually not considered high.
This is because urine tests are typically conducted using the first morning urine, which can be concentrated and may lead to a higher value.
Furthermore, elevated urobilinogen levels are often associated with excessive fatigue, liver disease, or hemolytic disorders.
Therefore, as long as your blood tests show no abnormalities, there is no need for excessive concern; regular follow-up appointments for monitoring are sufficient.

Additionally, the glomerular filtration rate (GFR) obtained from blood tests is an estimated value, and a GFR greater than 60 is considered normal.
However, it is important to note that since it is an estimate, there can be significant deviations in assessing kidney function when the value exceeds 60.
If you are particularly concerned about fluctuations in this value, it is advisable to consult a nephrologist, who may order more detailed tests to help you accurately assess your kidney function indices.
Lastly, regarding the blood glucose and hemoglobin A1c values you provided, generally, if there is no history of diabetes, medication treatment is not necessary.
However, regular follow-up appointments are still recommended.
Thank you for your inquiry.

Reply Date: 2018/11/22

More Info


Understanding urine test results, particularly concerning uribilinogen levels, can provide valuable insights into your health, especially in relation to liver function and potential underlying conditions. Let's break down your questions one by one.

1. Uribilinogen Levels and Urine Bilirubin: The presence of uribilinogen at "1+" and a negative result for urine bilirubin can indicate several things. Normally, bilirubin is produced from the breakdown of red blood cells and is processed by the liver. When bilirubin is present in urine, it usually suggests liver dysfunction or bile duct obstruction. However, since your bilirubin is negative, it suggests that there is no significant obstruction or liver damage at this time. The presence of uribilinogen, albeit at a low level, can be a normal finding, especially after gallbladder removal, as the liver's processing of bilirubin can change post-surgery. It is essential to correlate these findings with any symptoms you may have and your overall health status.

2. Kidney Function and Protein Levels: The discrepancy between your kidney function tests (glomerular filtration rate, GFR) and urine protein levels can indeed be confusing. A GFR of 96 is considered normal, while a GFR of 77.29 indicates a decline in kidney function. The presence of urine protein at "+/-" suggests that there may be a small amount of protein in your urine, which can be a sign of kidney stress or damage. Factors such as dehydration, exercise, or even temporary illness can affect these results. It is crucial to follow up with your healthcare provider to determine the cause of this decline and whether further testing, such as a 24-hour urine collection or additional blood tests, is necessary to clarify your kidney function.

3. Blood Sugar Levels: Your fasting blood sugar of 100 mg/dL and a hemoglobin A1c of 5.7% are within the range that suggests you are at risk for developing diabetes, but you are not yet diagnosed with it. The American Diabetes Association defines prediabetes as a fasting blood sugar between 100 and 125 mg/dL and an A1c between 5.7% and 6.4%. While you do not require treatment at this stage, it is essential to monitor your blood sugar levels regularly and make lifestyle changes, such as maintaining a healthy diet, exercising regularly, and managing your weight, to prevent progression to diabetes.

In summary, your urine test results, particularly the uribilinogen and bilirubin levels, suggest that your liver is functioning adequately post-surgery. The fluctuations in your kidney function tests warrant further investigation, and it would be prudent to discuss these results with your healthcare provider. Lastly, while your blood sugar levels indicate a risk for prediabetes, proactive lifestyle changes can help mitigate this risk. Regular follow-ups with your healthcare provider will be essential in managing these health concerns effectively.

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