Overuse of Antibiotic Eye Drops: Risks and Recovery Insights - Ophthalmology

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Overuse of antibiotic eye drops?


Due to severe itching in my eyes, I used "Shilong" antibiotic drops.
However, my eyes did not improve, so I pressed the bottle forcefully, administering about 20 drops into my eyes.
As a result, while the itching subsided, I experienced intense pain, and the color of my pupils became lighter.
I have stopped the medication for 7 days and have seen an ophthalmologist three times, but the doctor could not explain the severe pain and color change.
The doctor advised me to discontinue the medication and use preservative-free artificial tears, but my symptoms have not improved.
I would like to know: 1.
Could the excessive use of antibiotics and the preservatives in the drops cause thinning of the cornea or sclera? 2.
Could this lead to damage or pathology of the corneal endothelial cells? 3.
How can I alleviate the severe eye pain? 4.
How long will it take to recover?

Li Yucheng, 40~49 year old female. Ask Date: 2019/03/21

Dr. Gao Pilin reply Ophthalmology


Hello Mr.
Lee:
1.
Does the use of large amounts of antibiotics and preservatives in eye drops cause thinning of the cornea or sclera? It is unlikely.
Additionally, if you are instilling 20 drops at once, most of it will flow out, so there shouldn't be an issue of overdose.
2.
Does it cause damage or pathology to the corneal endothelial cells? It is unlikely.
3.
How can we alleviate severe eye pain? After discontinuing the medication, it should improve over time.
If the pain persists, it would be advisable to check for other factors, and please have a physician reassess.
4.
How long will it take to recover? It is best to rely on the clinical judgment of the examining physician.
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Please note that online responses are for reference only; if necessary, you should seek medical attention at a healthcare facility.
I hope to have the opportunity to serve you.
Gao Pilin

Reply Date: 2019/03/21

More Info


The overuse of antibiotic eye drops can lead to various complications, including corneal thinning, damage to the corneal endothelial cells, and other adverse effects. In your case, it sounds like you have experienced significant discomfort and changes in your eye condition after using the antibiotic drops excessively. Let’s address your questions one by one.

1. Impact of Excessive Antibiotic Use and Preservatives: Overusing antibiotic eye drops, especially those containing preservatives, can potentially lead to toxicity in the eye. Preservatives like benzalkonium chloride (BAK) are commonly found in many eye drops and can cause irritation and damage to the ocular surface, including the cornea and conjunctiva. This irritation can lead to inflammation and may contribute to the thinning of the cornea over time. However, the extent of this damage often depends on the specific formulation of the eye drops and the duration of exposure. If you have been using a high volume of drops, it is plausible that this could have contributed to your symptoms.

2. Corneal Endothelial Cell Damage: The corneal endothelium is a critical layer of cells that maintain corneal clarity by regulating fluid balance. Excessive use of antibiotic drops, especially those with preservatives, can lead to endothelial cell damage. This damage can manifest as corneal edema (swelling) and may result in visual disturbances. If the endothelial cells are compromised, it can lead to a decrease in corneal transparency and potentially cause long-term vision issues.

3. Managing Severe Eye Pain: To alleviate the severe pain you are experiencing, it is essential to follow your ophthalmologist's advice and discontinue the use of any potentially harmful medications. Using preservative-free artificial tears can help lubricate the eye and provide relief from dryness and irritation. Additionally, cold compresses applied gently to the eyes can help reduce inflammation and discomfort. If the pain persists, your ophthalmologist may consider prescribing stronger anti-inflammatory medications or other treatments to manage your symptoms effectively.

4. Recovery Timeline: The recovery time can vary significantly based on the extent of the damage and the underlying cause of your symptoms. Generally, if the irritation is due to preservative toxicity or superficial corneal damage, you may start to feel improvement within a few days to weeks after discontinuing the offending drops and using appropriate lubricants. However, if there is significant damage to the corneal endothelium or other structures, recovery may take longer, and ongoing monitoring by your eye care professional will be necessary.

In summary, it is crucial to communicate openly with your ophthalmologist about your symptoms and concerns. They may recommend further diagnostic tests, such as corneal topography or specular microscopy, to assess the condition of your cornea and endothelial cells. If you experience any worsening of symptoms or new issues, do not hesitate to seek immediate medical attention. Your eye health is paramount, and timely intervention can help prevent long-term complications.

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