Unexplained Warm Sensation in Urethra and Anus: Possible Causes and Concerns - Internal Medicine

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Unexplained mild warmth at the urethral and anal openings?


Hello Dr.
Lin, in the past few months, I have been experiencing unusual sensations in the palms of my hands, feeling swollen and warm.
When I use the restroom, I also feel a slight warmth around the urethral and anal areas, but there is no pain or frequent urination.
I had a comprehensive health check-up last month, and all the results were normal.
I started taking medication for depression around July of last year.
Could this be related to the medication, or is there another cause?

Zhu Baba, 60~69 year old female. Ask Date: 2019/04/30

Dr. Lin Wufu reply Internal Medicine


Hello Mr.
Zhu: It is difficult to determine whether this is related to medication or due to other reasons based solely on this description.
However, if the palms of your hands are simply feeling warm without any rash or pain, it is generally advisable to observe the situation first.
The sensation of heat at the urethral and anal openings is primarily a subjective change; if your health check showed no urinary tract infection in the urine test, immediate intervention is usually not necessary.
Antidepressant medications can indeed cause some sensory changes, but it seems that these changes are tolerable.
It is recommended not to discontinue the medication on your own due to these discomforts; you can discuss them with your doctor during your next appointment regarding your depression.

Reply Date: 2019/04/30

More Info


The sensation of warmth in the urethra and anus can be concerning, especially when it is unexplained and accompanied by other symptoms. In your case, the absence of pain, frequent urination, or other urinary symptoms is a positive sign, but it is still essential to consider various potential causes.

1. Medication Side Effects: You mentioned that you started taking medication for depression around July of last year. Certain antidepressants can cause various side effects, including changes in sensation. For instance, selective serotonin reuptake inhibitors (SSRIs) and other classes of antidepressants can sometimes lead to sexual side effects or altered sensations in the genital area. If you suspect that your medication might be contributing to these sensations, it is crucial to discuss this with your prescribing physician. They may consider adjusting your dosage or switching to a different medication.

2. Nerve Sensitivity: The warmth you are feeling could also be related to nerve sensitivity or neuropathy. This can occur due to various factors, including stress, anxiety, or even as a side effect of certain medications. If you have been experiencing increased stress or anxiety, this could potentially lead to heightened sensitivity in certain areas of your body.

3. Infection or Inflammation: While you mentioned that you do not have any pain or frequent urination, it is still worth considering the possibility of a mild infection or inflammation in the urinary tract or surrounding areas. Conditions such as urethritis or prostatitis can sometimes present with unusual sensations without the classic symptoms of pain or urgency. A urinalysis or further evaluation by a urologist may be warranted to rule out any underlying infections.

4. Psychological Factors: Sometimes, unexplained sensations can be linked to psychological factors. Anxiety and depression can manifest in various physical symptoms, including sensations of warmth or discomfort in different parts of the body. If you have been feeling anxious or stressed, this could contribute to the sensations you are experiencing.

5. Hormonal Changes: Hormonal fluctuations can also lead to changes in sensation. If you are experiencing any other symptoms related to hormonal changes, it might be worth discussing this with your healthcare provider.

6. Other Medical Conditions: There are other medical conditions that could lead to sensations of warmth in the genital area, such as diabetes or thyroid disorders. Since you have had a recent health check-up with normal results, it may be less likely, but it is still something to keep in mind.

In summary, while the sensations you are experiencing in your urethra and anus are not accompanied by significant symptoms, it is essential to consider the potential impact of your medication, psychological factors, and the possibility of mild infections or other medical conditions. I recommend discussing your symptoms with your healthcare provider, who may suggest further evaluation or adjustments to your treatment plan. Keeping a symptom diary, noting when the sensations occur and any other accompanying factors, can also be helpful for your doctor in determining the cause of your symptoms.

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