Do Avamys and Broen-C Affect the Effectiveness of EllaOne? - Pharmacology

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Will the contraceptive effect of the emergency contraceptive pill be reduced due to interactions with the following two medications?


I visited an ENT specialist yesterday due to nasal inflammation, and the doctor prescribed me the following two medications.
However, I am currently taking the contraceptive pill "Yaz," and I would like to ask if these two medications might interact with Yaz and potentially reduce its contraceptive effectiveness.
Thank you!
1.
Medication Name: Avamys Nasal Spray 27.5ug/50uL; 120D
Chinese Name: 艾敏釋鼻用噴液懸浮劑
2.
Medication Name: Broen-C Enteric F.C.
Tab
Chinese Name: 撲炎喜腸溶膜衣(黃色圓凸型)錠
Thank you very much for your assistance!

Xiao Guo, 20~29 year old female. Ask Date: 2019/04/30

Dr. Huang Shenggang reply Pharmacology


Thank you for your question: Regarding the oral contraceptive "Yueji," it contains two active ingredients, Drospirenone and Estradiol, as per the approval from the Ministry of Health and Welfare.
Additionally, based on the information you provided, the nasal spray "Aimin" contains Fluticasone Furoate, and the enteric-coated tablet "Puyanhxi" contains Bromelain and L-Cysteine HCl.
According to the IBM Micromedex drug interaction query, there are no drug interactions among these three medications, so you can rest assured.
Thank you.

Reply Date: 2019/04/30

More Info


When considering the interaction between Avamys Nasal Spray, Broen-C Enteric F.C. Tab, and EllaOne (a form of emergency contraception), it is essential to understand the pharmacological profiles of these medications and their potential interactions with hormonal contraceptives.

Avamys Nasal Spray contains Fluticasone Furoate, which is a corticosteroid used primarily for the treatment of allergic rhinitis and nasal inflammation. Corticosteroids like Fluticasone work by reducing inflammation and immune responses in the nasal passages. Importantly, Fluticasone does not have any known interactions with hormonal contraceptives, including EllaOne. Therefore, using Avamys should not affect the effectiveness of EllaOne or any other hormonal contraceptive methods.

Broen-C Enteric F.C. Tab contains Bromelain and L-Cysteine HCl. Bromelain is an enzyme derived from pineapples that is often used for its anti-inflammatory properties, while L-Cysteine is an amino acid that can help with various bodily functions, including antioxidant activity. Similar to Avamys, there are no documented interactions between Broen-C and hormonal contraceptives. Thus, taking Broen-C should not impact the effectiveness of EllaOne.

EllaOne (Ulipristal Acetate) is a selective progesterone receptor modulator used as emergency contraception. It works primarily by delaying ovulation and altering the endometrium to prevent implantation. The effectiveness of EllaOne can be influenced by certain medications, particularly those that induce liver enzymes, such as some anticonvulsants and herbal supplements like St. John's Wort. However, neither Avamys nor Broen-C falls into this category.

In summary, based on current medical knowledge and available literature, neither Avamys Nasal Spray nor Broen-C Enteric F.C. Tab will affect the effectiveness of EllaOne. You can safely use these medications without worrying about compromising the contraceptive efficacy of EllaOne or any other hormonal contraceptive you may be taking.

It is also worth noting that if you experience any side effects from EllaOne, such as headaches or nausea, these are common and can occur as part of the medication's side effects. If these symptoms are bothersome, it is advisable to consult with your healthcare provider for further management.

In conclusion, you can be reassured that the combination of Avamys and Broen-C with EllaOne does not pose any risk of reducing the effectiveness of your emergency contraception. Always consult your healthcare provider if you have concerns about medication interactions or if you experience any unusual symptoms while taking these medications.

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