Blood in Urine: Normal Urinalysis and Next Steps - Urology

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Hematuria with normal urinalysis?


In March, I discovered blood in my urine and went to see a doctor the next day.
The doctor prescribed antibiotics, and after completing the course, my follow-up urine test results were normal.
At the end of April, I noticed blood in my urine again.
I took the afternoon off to see a doctor, and the urine test results that day were normal as well.
The doctor did not prescribe any medication and sent me home.
What should I do since my urine tests have consistently returned normal after the episodes of hematuria? I have ulcerative colitis and am taking mesalamine; could this have any impact? I informed the doctor about my medication, and he stated that there is no effect in the UK.

Sally, 20~29 year old female. Ask Date: 2019/04/30

Dr. Xu Wencang reply Urology


If there is persistent hematuria, the cause must be investigated.
Continuous outpatient follow-up is required.

Reply Date: 2019/04/30

More Info


When it comes to the presence of blood in urine, also known as hematuria, it can be a concerning symptom that warrants further investigation, especially if it recurs. In your case, you have experienced episodes of hematuria, but subsequent urinalysis has returned normal results. This situation raises several important considerations regarding the management and potential underlying causes of your symptoms.

Firstly, it is essential to understand that hematuria can be classified into two types: gross hematuria, where blood is visible to the naked eye, and microscopic hematuria, where blood is only detectable under a microscope. The fact that you have experienced visible blood in your urine suggests that there may be an underlying issue that needs to be addressed, even if your follow-up urinalysis results appear normal.

Given your history of ulcerative colitis, it is crucial to consider how this condition and the medications you are taking may influence your urinary symptoms. While your doctor has indicated that the medication you are taking (likely mesalamine or a similar agent) does not have a known impact on urinary health, it is still important to monitor any changes in your symptoms closely. Ulcerative colitis can sometimes lead to complications that may affect the urinary tract, including inflammation or infection.

In terms of next steps, here are some recommendations:
1. Follow-Up with a Specialist: Since you have a history of hematuria, it would be prudent to consult a urologist. They can perform a thorough evaluation, including a detailed history and physical examination, to assess for potential causes of your hematuria. This may include a review of your gastrointestinal condition and its possible implications for your urinary symptoms.

2. Imaging Studies: If hematuria persists or recurs, imaging studies such as a renal ultrasound or a CT scan of the abdomen and pelvis may be warranted. These tests can help identify any structural abnormalities in the kidneys or urinary tract, such as stones, tumors, or other lesions.

3. Cystoscopy: If the imaging studies do not reveal a clear cause, a cystoscopy may be recommended. This procedure involves inserting a thin tube with a camera into the bladder through the urethra, allowing direct visualization of the bladder and urethra. It can help identify any lesions, inflammation, or other abnormalities that may be causing the bleeding.

4. Regular Monitoring: Since you have experienced episodes of hematuria, regular follow-up urinalysis may be beneficial. This can help track any changes in your urinary health and ensure that any new developments are addressed promptly.

5. Review Medications: Continue to discuss your medications with your healthcare provider. While your doctor has indicated that your current medication does not affect urinary health, it is always good practice to review all medications and supplements you are taking to rule out any potential side effects.

6. Lifestyle and Dietary Considerations: Pay attention to any dietary factors that may influence your urinary health. Certain foods, beverages, or supplements can sometimes affect urine color or composition. Keeping a diary of your symptoms, dietary intake, and any medications can provide valuable information for your healthcare provider.

In conclusion, while your recent urinalysis results may be normal, the recurrence of hematuria, especially in the context of ulcerative colitis, warrants further investigation. Engaging with a urologist and considering imaging studies or cystoscopy can help identify any underlying issues. Regular monitoring and open communication with your healthcare team are essential in managing your symptoms effectively.

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