Anemia: What to Do When Blood Tests Show Abnormal Results - Family Medicine

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Blood disorders


During each health check-up, I have been told that I have anemia.
This time, the abnormal results from my check-up were as follows: Mean Corpuscular Volume (MCV) 61.4 (normal range 80-100), Hemoglobin 19.9 (normal range 26-34), Red Blood Cell count 6.87 (normal range 4.5-5.9), Red Cell Distribution Width (RDW-CV) 17.5 (normal range 11.5-14.5), and RDW-SD 36.2 (normal range 37-50).
Therefore, I underwent tests to confirm whether I have thalassemia or iron deficiency anemia.
The results for iron deficiency anemia showed 147.3 (normal range 27-300), and for thalassemia, A1 was 97.7 (normal range 96.8-97.8) and A2 was 2.3 (normal range 2.2-3.2), all of which were normal values.
I would like to know how I can address this anemia issue or if I need to undergo further testing.

Allen, 20~29 year old female. Ask Date: 2019/05/22

Dr. Liao Yaopan reply Family Medicine


Hello, to determine if you have anemia, it is important to look at the levels of hemoglobin.
However, the units and reference values for hemoglobin in the report you provided seem to differ from commonly used clinical standards.
If anemia is indeed present, and the mean corpuscular volume (MCV) is low, it suggests microcytic anemia.
The next step would be to differentiate the causes, which are commonly thalassemia or iron deficiency anemia.
However, if hemoglobin electrophoresis results are normal, it may indicate the presence of a genetic trait for thalassemia without causing disease symptoms.
If non-iron deficiency anemia has been ruled out, hereditary factors typically do not require special treatment.
It is advisable to consult a hematologist for further evaluation.
Please note that online consultations are not equivalent to in-person medical visits and cannot provide diagnoses or treatment recommendations.
Changhua Hospital cares about your health.

Reply Date: 2019/05/22

More Info


Understanding anemia and its implications can be quite complex, especially when blood tests reveal abnormal results. Based on the information provided, it appears that you have been diagnosed with some form of anemia, as indicated by your blood test results. Let's break down the findings and discuss potential next steps.


Blood Test Results Interpretation
1. Mean Corpuscular Volume (MCV): Your MCV is reported as 61.4, which is significantly lower than the normal range (80-100). This suggests microcytic anemia, which is often associated with iron deficiency or thalassemia (including Mediterranean anemia).

2. Hemoglobin (Hb): Your hemoglobin level is 19.9, which is also below the normal range (26-34). Low hemoglobin levels indicate that your blood is not carrying enough oxygen, which can lead to symptoms such as fatigue, weakness, and shortness of breath.

3. Red Blood Cell Count (RBC): Your RBC count is 6.87, which is elevated compared to the normal range (4.5-5.9). This can occur in response to anemia as the body attempts to compensate for low hemoglobin levels by producing more red blood cells.

4. Red Cell Distribution Width (RDW): Your RDW-CV is 17.5 (normal range 11.5-14.5), and RDW-SD is 36.2 (normal range 37-50). An elevated RDW can indicate a variation in red blood cell size, which is often seen in different types of anemia.


Possible Causes of Your Anemia
Given your test results, the following conditions could be contributing to your anemia:
- Iron Deficiency Anemia: Although your iron levels are within the normal range, it is essential to consider that iron stores may still be depleted. Further tests, such as ferritin levels, could provide more insight.

- Thalassemia: Your results for Mediterranean anemia (thalassemia) show normal values, but it may still be worth investigating if you have a mild form or if there are other genetic factors at play.

- Chronic Disease: Sometimes, chronic diseases can lead to anemia of chronic disease, which may not be evident in standard iron studies.


Next Steps
1. Consult a Hematologist: Given the complexity of your results, it would be prudent to consult a hematologist. They can provide a more comprehensive evaluation and may recommend additional tests, such as a peripheral blood smear, reticulocyte count, or further iron studies.

2. Further Testing: You may need tests for vitamin B12 and folate levels, as deficiencies in these vitamins can also lead to anemia. Additionally, tests for chronic inflammatory conditions or bone marrow function may be warranted.

3. Dietary Assessment: Evaluate your diet to ensure you are consuming adequate iron-rich foods (such as red meat, beans, lentils, and fortified cereals) and vitamin C to enhance iron absorption. If you are vegetarian or vegan, consider plant-based sources of iron and possibly supplementation.

4. Monitor Symptoms: Keep track of any symptoms you experience, such as fatigue, dizziness, or paleness, and report these to your healthcare provider. This information can help guide your treatment plan.

5. Follow-Up: Regular follow-up blood tests may be necessary to monitor your hemoglobin levels and overall blood health as you implement dietary changes or treatment plans.


Conclusion
Anemia can be a multifaceted condition requiring a thorough investigation to determine its cause. Your abnormal blood test results indicate that further evaluation is necessary to identify the underlying issue and develop an appropriate treatment plan. Engaging with a healthcare professional, particularly a hematologist, will be crucial in navigating this process effectively.

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