Managing Urinary Tract Infections in Pregnant Women: Safety of Antibiotics - Obstetrics and Gynecology

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Urinary tract infection in pregnant women?


Hello Doctor,
I am currently 32 weeks pregnant and have been experiencing difficulty urinating this week, along with a burning sensation and some pain.
I visited a urologist today, and the doctor diagnosed me with inflammation and prescribed antibiotics, specifically cefixime 100 mg for a total of 7 days.
He mentioned that at this stage of pregnancy, the baby is sufficiently developed, and if I do not take the medication, there is a risk of systemic infection, so he recommended that I take it.
I would like to ask if this medication is suitable for pregnant women at this stage? Thank you!

Ling, 30~39 year old female. Ask Date: 2020/01/18

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, this medication generally does not have any effects this week, so please rest assured.
Wishing you good health.

Reply Date: 2020/01/18

More Info


Managing urinary tract infections (UTIs) during pregnancy is a critical aspect of prenatal care, as untreated infections can lead to serious complications for both the mother and the developing fetus. Your concerns about the safety of antibiotics during pregnancy, particularly at 32 weeks, are valid and important to address.

First, it's essential to understand that UTIs are common during pregnancy due to physiological changes in the urinary tract. The growing uterus can exert pressure on the bladder, leading to incomplete emptying and creating an environment conducive to bacterial growth. Symptoms such as burning during urination, increased frequency, and urgency can indicate a UTI, and in some cases, these infections can escalate to pyelonephritis, a more severe kidney infection that can pose risks to both mother and baby.

Regarding the antibiotic prescribed, cefixime is a third-generation cephalosporin antibiotic. It is generally considered safe for use during pregnancy and falls under category B in the FDA pregnancy classification system. This means that animal studies have not shown any risk to the fetus, and there are no adequate and well-controlled studies in pregnant women. However, it is always crucial to weigh the benefits of treating the infection against any potential risks.

Your doctor’s recommendation to take cefixime is based on the need to prevent complications from an untreated UTI, which can include systemic infection (sepsis) and preterm labor. At 32 weeks, the fetus is well-developed, and the risks associated with the infection itself often outweigh the risks of antibiotic treatment.
In terms of managing UTIs during pregnancy, here are some preventive measures and considerations:
1. Hydration: Drinking plenty of water helps dilute the urine and flush out bacteria from the urinary tract. Aim for at least 8-10 glasses of water daily.

2. Urination Habits: Urinate frequently and do not hold it in. Emptying the bladder regularly can help prevent bacteria from multiplying.

3. Post-Intercourse Hygiene: Urinating after sexual intercourse can help flush out any bacteria that may have entered the urinary tract.

4. Wipe Properly: Always wipe from front to back after using the toilet to prevent bacteria from the rectal area from entering the urethra.

5. Cranberry Products: Some studies suggest that cranberry juice or supplements may help prevent UTIs, although the evidence is mixed. Consult your healthcare provider before using these as a preventive measure.

6. Regular Check-ups: Regular prenatal visits are crucial for monitoring and managing any potential infections. If you experience symptoms of a UTI, seek medical attention promptly.

7. Follow-Up: After completing the antibiotic course, it’s advisable to have a follow-up urine test to ensure that the infection has cleared.

In summary, cefixime is considered safe for use during pregnancy, particularly at 32 weeks, and is necessary to treat your UTI effectively. It’s essential to follow your healthcare provider's recommendations and maintain open communication regarding any concerns you may have about medications or symptoms. Always prioritize your health and the health of your baby by adhering to prescribed treatments and preventive measures. If you have further questions or experience any new symptoms, do not hesitate to reach out to your healthcare provider.

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