Steroid Use in Pregnancy: Managing Hyperthyroidism Medications

Q: Steroid Use in Pregnancy: Managing Hyperthyroidism Medications

Hello： <br>1. <br>Carbizo (Carbimazole) and Dihydrex (an antihistamine) are not classified as steroid medications. <br>Carbizo is commonly used to treat hyperthyroidism, and about 5% of patients may experience mild side effects, typically occurring within the first two months of

Steroid dosage, medications during pregnancy, hyperthyroidism?

1.
The medications used to treat hyperthyroidism, Carbizo (Carbimazole) and Propylthiouracil (PTU), do not contain steroids.

2.
If pregnancy is confirmed, it is important to consult with your healthcare provider before continuing the use of Carbizo or Propylthiouracil, as the safety of these medications during pregnancy needs to be evaluated on a case-by-case basis.
Thank you for your understanding.

Ms. Zeng, 20~29 year old female. Ask Date: 2020/02/21

Dr. Liao Lingmei reply Pharmacology

Hello:
1.
Carbizo (Carbimazole) and Dihydrex (an antihistamine) are not classified as steroid medications.
Carbizo is commonly used to treat hyperthyroidism, and about 5% of patients may experience mild side effects, typically occurring within the first two months of treatment, including itching.
Antihistamines like Dihydrex can be used to manage this symptom.
2.
Regarding the risks to the fetus and newborn: There is insufficient evidence to suggest that the use of antithyroid medications is associated with congenital abnormalities (teratogenic effects).
However, the risks posed by antithyroid medications to the fetus include hypothyroidism and goiter.
Some reports indicate a potential for transient fetal hypothyroidism, with an incidence of approximately 1% in newborns of mothers receiving antithyroid treatment, which is also related to the dosage of antithyroid medication taken by the mother.
Dihydrex is considered to have a relatively higher safety profile compared to Carbizo.
3.
Pregnant women should follow medication guidelines based on a physician's assessment and communication.

Wishing you health and happiness!

Reply Date: 2020/02/21

More Info

When it comes to managing hyperthyroidism during pregnancy, it is crucial to understand the implications of medication use, especially regarding the safety of the fetus. Your questions about the medications Carbimazole (often referred to as "carbizo") and Propylthiouracil (PTU, which is sometimes referred to as "驅異樂") are very pertinent.

1. Steroid Content in Medications: Carbimazole is an antithyroid medication that is not a steroid. It works by inhibiting the synthesis of thyroid hormones, thus helping to manage hyperthyroidism. On the other hand, PTU is also an antithyroid medication and does not contain steroids either. Both medications are classified as thionamides and are commonly used to treat hyperthyroidism, particularly in pregnant women. However, it is essential to note that while these medications are not steroids, they do have implications for pregnancy and fetal health.

2. Continuing Medication During Pregnancy: If you discover that you are pregnant while taking Carbimazole or PTU, it is crucial to consult your healthcare provider immediately. Carbimazole is classified as a pregnancy category D medication, which means there is evidence of risk to the fetus, but the benefits may outweigh the risks in certain situations. PTU is generally preferred during the first trimester of pregnancy due to its safety profile compared to Carbimazole.
The management of hyperthyroidism in pregnancy is a delicate balance. Uncontrolled hyperthyroidism can lead to serious complications for both the mother and the fetus, including preterm birth, low birth weight, and even fetal loss. Therefore, it is often necessary to continue treatment to maintain thyroid hormone levels within a safe range.
If you are experiencing side effects such as skin itching from Carbimazole, it is essential to discuss this with your doctor. They may consider switching you to PTU or adjusting your dosage to minimize side effects while ensuring effective management of your hyperthyroidism.

In summary, while Carbimazole and PTU do not contain steroids, their use during pregnancy must be carefully monitored. Always consult with your healthcare provider before making any changes to your medication regimen, especially when pregnant. Regular monitoring of thyroid function and fetal health is essential to ensure the best outcomes for both you and your baby.

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