Interactions Between Birth Control Pills and Antidepressants: What You Need to Know - Pharmacology

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The interaction between contraceptive pills and antidepressants?


Hello, I am currently taking Diane and today my psychiatrist prescribed me Mocalm.
I am wondering if taking both together will reduce the effectiveness of the birth control pill.
Additionally, I have a sleeping pill called Lendormin; will it also affect the efficacy of the birth control pill? Thank you.

Xiao Yue, 20~29 year old female. Ask Date: 2020/03/02

Dr. Hou Fangmin reply Pharmacology


Hello, Miss Xiaoyue:
1.
Diane contains Cyproterone 2mg and Ethinylestradiol 0.035mg.
This medication is metabolized by the liver and may induce the accelerated clearance of hormones (for example, Lendormin (Brotizolam), which can reduce the contraceptive effectiveness.
2.
Grapefruit juice can increase the concentration of Diane (either estrogen or progestin, or both) in the bloodstream, so it is advisable to avoid consuming grapefruit juice.
3.
Antibiotics that interfere with the enterohepatic circulation, such as penicillins and tetracyclines, may lower the enterohepatic circulation of estrogen and reduce the concentration of Ethinylestradiol in Diane.
Fortunately, you are not taking antibiotics.
4.
Mocalm (Melitracen HCl, Flupentixol) does not have any interactions with Diane.
Is this response satisfactory for you? Wishing you peace and good health.

Reply Date: 2020/03/02

More Info


When it comes to the interactions between birth control pills and antidepressants, as well as other medications like sleep aids, it's essential to understand how these drugs can affect each other and your overall health.
Firstly, the birth control pill you mentioned, Dai Lian (戴麗安), is a combination hormonal contraceptive that contains estrogen and progestin. Its primary function is to prevent ovulation, thereby reducing the chances of pregnancy. However, certain medications can potentially interfere with its effectiveness.

Mocalm, which is a muscle relaxant often prescribed for anxiety and muscle spasms, does not have a known interaction with birth control pills that would reduce their effectiveness. However, it is always wise to consult with your healthcare provider about any medications you are taking to ensure there are no unforeseen interactions.

On the other hand, Lendormin (戀多眠), a sleep aid that contains the active ingredient nitrazepam, is a benzodiazepine. While there is no direct evidence suggesting that benzodiazepines significantly affect the efficacy of birth control pills, they can have sedative effects that may alter your mood and cognitive functions. It is crucial to be cautious when combining these medications, as both can affect your mental state.

The primary concern with combining antidepressants and birth control pills is the potential for the antidepressant to affect the metabolism of the contraceptive. Some antidepressants, particularly those in the class of selective serotonin reuptake inhibitors (SSRIs), can interact with hormonal contraceptives, but the effects vary depending on the specific medication. For instance, certain SSRIs may increase the levels of estrogen in the body, while others may not have any significant effect.

Moreover, some medications can induce liver enzymes that metabolize hormonal contraceptives more quickly, potentially leading to decreased effectiveness. This is particularly true for certain anticonvulsants and antibiotics, but it is less common with antidepressants. Therefore, it is essential to discuss your specific antidepressant with your healthcare provider to understand any potential interactions.

In summary, while Mocalm and Lendormin do not have well-documented interactions with birth control pills, it is crucial to maintain open communication with your healthcare provider. They can provide personalized advice based on your medical history and the specific medications you are taking.
Additionally, if you experience any side effects or changes in your mood or health while taking these medications, it is essential to report them to your doctor. They may need to adjust your treatment plan or monitor you more closely to ensure your safety and well-being.

In conclusion, always consult with your healthcare provider regarding any concerns about medication interactions, especially when it comes to birth control and mental health medications. Your health and safety should always be the top priority, and your doctor can help you navigate these complexities effectively.

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