Mediterranean Anemia: Severity and Breathing Issues Explained - Cardiology

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Mediterranean anemia


Hello~ The lab results show RBC 6.88, Hb 14.5, MCV 66.2, MCH 21, and MCHC 31.8.
Given the known diagnosis of thalassemia, are these values considered severe? Additionally, I sometimes feel short of breath and take deep breaths; is this related to anemia?

Liu Xiansheng, 20~29 year old female. Ask Date: 2020/03/10

Dr. He Dongjin reply Cardiology


Hello, it's not serious and is not related to anemia, so there's no need to worry.
Changhua Hospital cares about you.

Reply Date: 2020/03/10

More Info


Mediterranean anemia, commonly known as thalassemia, is a genetic blood disorder characterized by reduced hemoglobin production. The values you provided from your blood test indicate that you have a high red blood cell count (RBC of 6.88), a hemoglobin level (Hb) of 14.5, and low mean corpuscular volume (MCV) of 66.2, which suggests microcytic anemia. The mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) values also support this finding.
In thalassemia, the severity of the condition can vary significantly depending on the specific type of thalassemia you have (alpha or beta) and the number of affected genes. Generally, individuals with thalassemia trait (minor) may have mild anemia and often do not experience significant symptoms. However, those with more severe forms, such as beta-thalassemia major, may require regular blood transfusions and experience more pronounced symptoms.

Your hemoglobin level of 14.5 g/dL is within the normal range for adults, which typically falls between 13.5 to 17.5 g/dL for men and 12.0 to 15.5 g/dL for women. However, the low MCV indicates that your red blood cells are smaller than average, which is characteristic of thalassemia. The severity of your condition cannot be determined solely by these values; it is essential to consider your clinical symptoms, family history, and possibly further genetic testing.

Regarding your experience of feeling short of breath and needing to take deep breaths, this can indeed be related to anemia. When the body is anemic, there is a reduced capacity to carry oxygen in the blood, which can lead to feelings of fatigue, weakness, and breathlessness. The body may respond to low oxygen levels by increasing the respiratory rate or taking deeper breaths in an attempt to compensate for the lack of oxygen being delivered to tissues. This compensatory mechanism can lead to sensations of breathlessness, especially during physical exertion or stress.

It is also important to consider other potential causes of your breathing difficulties. Conditions such as asthma, chronic obstructive pulmonary disease (COPD), or even anxiety can contribute to feelings of breathlessness. Therefore, it is advisable to discuss these symptoms with your healthcare provider, who may recommend further evaluation, including pulmonary function tests or imaging studies, to rule out other respiratory conditions.

In summary, while your blood test results indicate that you have thalassemia, the severity of your condition cannot be determined solely based on these values. Your symptoms of breathlessness may be related to your anemia, but it is crucial to explore other potential causes as well. Regular follow-up with your healthcare provider is essential to monitor your condition and manage any symptoms effectively. If you experience worsening symptoms, such as increased shortness of breath, fatigue, or any other concerning signs, seek medical attention promptly.

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