Can You Combine Cialis 5mg Daily with UroLift 4mg for BPH?

Can I take Cialis 5mg daily in combination with the prostate enlargement medication UroLift 4mg?

Can I take Cialis 5mg daily together with UroXatral 4mg for benign prostatic hyperplasia? The Cialis leaflet states that it should not be used in combination with alpha-blockers, and UroXatral is an alpha-1A blocker.
Should I wait a certain amount of time before taking them separately? I have mild prostate enlargement, and my doctor has advised me to take it for six months, but I am experiencing insufficient erection hardness, and my doctor recommended taking Cialis 5mg daily.

jack, 50~59 year old female. Ask Date: 2020/03/11

Dr. Li Xinyi reply Urology

The combination of alpha-blockers is not an absolute contraindication; the absolute contraindication is the concurrent use of cardiovascular vasodilators such as nitrates, as this can lead to severe hypotension.
However, Urokinase is one of the prostate medications that has the least impact on blood pressure.
The key point is to monitor blood pressure closely and pay attention to any changes to determine whether it is appropriate to take the medication.

Reply Date: 2020/03/11

More Info

When considering the combination of Cialis (tadalafil) 5mg daily with UroLift (silodosin) 4mg for the treatment of benign prostatic hyperplasia (BPH), it is important to understand the pharmacological profiles of both medications and their potential interactions.

Cialis is a phosphodiesterase type 5 (PDE5) inhibitor, primarily used to treat erectile dysfunction and sometimes prescribed for BPH due to its ability to relax smooth muscle in the prostate and bladder neck, thereby improving urinary flow. UroLift, on the other hand, is an alpha-1 adrenergic blocker that helps to relieve urinary symptoms associated with BPH by relaxing the muscles in the prostate and bladder neck.

The concern regarding the combination of these two medications arises from the fact that both can lower blood pressure. While there is no absolute contraindication for using Cialis and UroLift together, it is essential to monitor blood pressure closely. Patients may experience hypotension (low blood pressure), especially when standing up quickly, which can lead to dizziness or fainting. Therefore, it is advisable to check blood pressure regularly and be cautious about sudden changes in body position.

Regarding the specific concern about the interaction between Cialis and alpha blockers like UroLift, the prescribing information for Cialis does indicate caution when combining it with alpha blockers. This is primarily due to the risk of additive hypotensive effects. However, many healthcare providers do prescribe these medications together, especially in cases where patients have both erectile dysfunction and BPH symptoms, as the benefits may outweigh the risks.

If you are considering taking both medications, it is crucial to follow your healthcare provider's guidance. They may recommend starting with lower doses or spacing out the timing of the medications to minimize the risk of side effects. For example, taking Cialis in the morning and UroLift in the evening may help reduce the likelihood of experiencing low blood pressure.

Additionally, it is important to communicate any side effects you experience while on these medications to your healthcare provider. If you notice symptoms such as dizziness, lightheadedness, or unusual fatigue, these could be signs of hypotension, and your doctor may need to adjust your treatment plan.

In summary, while it is generally considered safe to combine Cialis 5mg daily with UroLift 4mg for BPH, close monitoring of blood pressure and communication with your healthcare provider are essential. Always follow your doctor's recommendations regarding medication use and report any concerning symptoms promptly. This approach will help ensure that you manage both your BPH symptoms and erectile dysfunction effectively while minimizing the risk of adverse effects.

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