Should I Continue Taking Progesterone After Possible Implantation Bleeding? - Obstetrics and Gynecology

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I am unsure whether I should continue taking progesterone?


Menstruation started on February 12.
Due to slow follicle development, ovulation induction injections were administered until February 26.
The ovulation trigger was given on the evening of February 27, and artificial insemination was performed on February 29.
The next day, I began daily supplementation of progesterone twice a day.
A follow-up appointment is scheduled for March 17.
However, on March 10, I noticed brown discharge.
During the follow-up, the doctor mentioned that it was still unclear whether it was menstrual bleeding or implantation bleeding, so I was given an injection of progesterone oil to support the pregnancy.
The doctor also mentioned that if it were menstrual bleeding, the flow would increase, and I could stop taking progesterone.
Today is the 13th, but the brown discharge has continued without increasing in volume or turning bright red.
This morning, I couldn't resist and took a pregnancy test, which showed only one line (disappointing).
I would like to know if there is still a chance for a positive result in a few days, whether I should continue progesterone supplementation, or if the brown discharge indicates that menstruation has started.
If I am not pregnant, will taking progesterone prevent menstruation?

Ting, 30~39 year old female. Ask Date: 2020/03/13

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, it is possible that you are not pregnant, but still finish taking the progesterone and then take a pregnancy test.
Wishing you good health.

Reply Date: 2020/03/13

More Info


When it comes to the question of whether to continue taking progesterone after experiencing possible implantation bleeding, it is essential to consider several factors related to your situation. Based on the timeline you've provided, it appears that you underwent assisted reproductive technology, specifically artificial insemination, and have been supplementing with progesterone to support the luteal phase of your cycle.
Implantation bleeding can occur when a fertilized egg attaches to the lining of the uterus, which typically happens about 6 to 12 days after conception. The brownish discharge you are experiencing could potentially be implantation bleeding, but it could also be a sign of an impending menstrual period. The key here is that the color and consistency of the discharge, along with the timing, can provide clues about what is happening in your body.

Since you have been advised by your doctor to continue progesterone supplementation, it is generally recommended to follow that guidance until you have a clear indication of whether you are pregnant or not. Progesterone plays a crucial role in maintaining the uterine lining and supporting early pregnancy. If you stop taking it prematurely, it could lead to a decrease in hormone levels that might affect the viability of a potential pregnancy.

Regarding your concern about the home pregnancy test showing only one line, it is important to note that home pregnancy tests are most accurate when taken after a missed period. If you tested too early, it might not detect the pregnancy hormone (hCG) even if you are pregnant. However, if you continue to see only one line in subsequent tests, it may indicate that you are not pregnant.

If the brown discharge persists without increasing in volume or changing to a brighter red, it may not necessarily mean that your period has started. However, if you notice an increase in flow or the discharge becomes more like a typical menstrual period, it could indicate that your body is preparing to menstruate.

In summary, here are some recommendations based on your situation:
1. Continue Progesterone: Unless your healthcare provider advises otherwise, continue taking progesterone as prescribed. It can help maintain the uterine lining and support a potential pregnancy.

2. Monitor Symptoms: Keep track of the discharge. If it changes in color, consistency, or volume, or if you experience any additional symptoms such as cramping or pain, contact your healthcare provider.

3. Follow Up with Your Doctor: Since you have a follow-up appointment scheduled, discuss your concerns about the discharge and the pregnancy test results with your doctor. They may recommend further testing, such as a blood test for hCG, which can provide a more definitive answer regarding pregnancy.

4. Understand the Role of Progesterone: If you are not pregnant, stopping progesterone may lead to the onset of your period. However, it is not advisable to stop it without medical guidance, as it could disrupt your cycle.

5. Emotional Support: It is natural to feel anxious or disappointed during this time. Consider reaching out to a support group or a counselor who specializes in fertility issues if you need emotional support.

In conclusion, while the situation can be uncertain, following your doctor's advice and monitoring your symptoms closely will be crucial in navigating this period.

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