Should You Continue Progesterone After Unexpected Bleeding? - Obstetrics and Gynecology

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Bleeding during progesterone therapy?


Hello Doctor, I apologize for the interruption.
I have a sudden situation I would like to consult you about.
I underwent a polypectomy with a rapid clean knife on May 14, and during my follow-up appointment on May 24, the doctor prescribed progesterone due to endometrial hyperplasia.
I started taking it for 14 days, but I have three days of medication left.
Today, I experienced sudden bleeding.
Should I continue taking the remaining three days of progesterone? Since the bleeding occurred suddenly, waiting for my follow-up appointment would exceed the medication period.
Thank you for your response.

Amber, 50~59 year old female. Ask Date: 2024/06/04

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, please continue taking your medication until it's finished, and then return to the obstetrics and gynecology clinic.
Wishing you good health.

Reply Date: 2024/06/04

More Info


When it comes to unexpected bleeding while on progesterone therapy, it's essential to understand the context of your situation and the potential implications of continuing or discontinuing the medication. Progesterone is often prescribed to help regulate menstrual cycles, support pregnancy, or manage conditions related to hormonal imbalances, such as endometrial hyperplasia, which you mentioned in your case.

Firstly, it’s important to note that unexpected bleeding can occur for various reasons, even when taking hormonal medications like progesterone. This bleeding could be a breakthrough bleed, which is relatively common, especially in the initial stages of hormone therapy. It can also indicate that the body is adjusting to the medication or that the dosage may need to be reevaluated.

Given that you had a polypectomy (removal of polyps) and were prescribed progesterone to address endometrial hyperplasia, the sudden onset of bleeding could be concerning. However, it does not automatically mean that you should stop taking the medication. Here are some considerations:
1. Consult Your Healthcare Provider: The best course of action is to reach out to your healthcare provider as soon as possible. They can provide personalized advice based on your medical history, the specifics of your surgery, and the current situation. If you cannot reach them immediately, consider whether you can wait until your next scheduled appointment or if you need to seek urgent care.

2. Continue the Medication: In many cases, if the bleeding is light and not accompanied by severe pain or other concerning symptoms, it may be advisable to continue taking the progesterone as prescribed. Stopping the medication abruptly could lead to further hormonal imbalances or complications.

3. Monitor Symptoms: Keep track of the bleeding—note the amount, duration, and any accompanying symptoms (such as pain, dizziness, or unusual discharge). This information will be valuable for your healthcare provider when assessing your condition.

4. Possible Adjustments: If the bleeding is heavy or persistent, your doctor may need to adjust your treatment plan. This could involve changing the dosage of progesterone or considering other therapeutic options.

5. Understanding Breakthrough Bleeding: Breakthrough bleeding can occur for various reasons, including hormonal fluctuations, the presence of fibroids or polyps, or even stress. It’s essential to differentiate between normal variations and signs of a more serious issue.

6. Follow-Up Care: Since you had surgery recently, follow-up appointments are crucial. Ensure you attend these appointments to monitor your recovery and the effectiveness of the progesterone therapy.

In summary, while unexpected bleeding during progesterone therapy can be concerning, it does not necessarily mean you should stop the medication without consulting your healthcare provider. Continue taking the medication unless advised otherwise, monitor your symptoms, and seek professional guidance to ensure your health and safety. Your healthcare provider will be the best resource to help you navigate this situation effectively.

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